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Bispecific antibody against sclerostin and DKK1 improves bone health and reduces bone marrow adipose tissue accumulation in experimental chronic kidney disease.

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Title: Bispecific antibody against sclerostin and DKK1 improves bone health and reduces bone marrow adipose tissue accumulation in experimental chronic kidney disease.
Authors: Promruk W; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK. W.Promruk@sms.ed.ac.uk.; Chulabhorn Royal Academy, Bangkok, Thailand. W.Promruk@sms.ed.ac.uk., Jayash SN; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Chutoe C; Edinburgh Cancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Ke HZ; Angitia Biopharmaceuticals (Angitia Incorporated Limited), Guangzhou, China and Westlake Village, Westlake Village, CA, USA., Liu X; Angitia Biopharmaceuticals (Angitia Incorporated Limited), Guangzhou, China and Westlake Village, Westlake Village, CA, USA., Wade RL; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., von Kriegsheim A; Edinburgh Cancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Cawthorn WP; Institute for Neuroscience and Cardiovascular Research, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK., Staines KA; Centre for Lifelong Health, School of Applied Sciences, University of Brighton, Brighton, UK., Stephen LA; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Farquharson C; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK. colin.farquharson@roslin.ed.ac.uk.
Source: Bone research [Bone Res] 2026 Jul 15; Vol. 14 (1). Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: West China School of Stomatology, Sichuan University Country of Publication: China NLM ID: 101608652 Publication Model: Electronic Cited Medium: Print ISSN: 2095-4700 (Print) Linking ISSN: 20954700 NLM ISO Abbreviation: Bone Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Bispecific antibody against sclerostin and DKK1 improves bone health and reduces bone marrow adipose tissue accumulation in experimental chronic kidney disease.
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  Data: <searchLink fieldCode="AU" term="%22Promruk+W%22">Promruk W</searchLink>; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK. W.Promruk@sms.ed.ac.uk.; Chulabhorn Royal Academy, Bangkok, Thailand. W.Promruk@sms.ed.ac.uk.<br /><searchLink fieldCode="AU" term="%22Jayash+SN%22">Jayash SN</searchLink>; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Chutoe+C%22">Chutoe C</searchLink>; Edinburgh Cancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Ke+HZ%22">Ke HZ</searchLink>; Angitia Biopharmaceuticals (Angitia Incorporated Limited), Guangzhou, China and Westlake Village, Westlake Village, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Angitia Biopharmaceuticals (Angitia Incorporated Limited), Guangzhou, China and Westlake Village, Westlake Village, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wade+RL%22">Wade RL</searchLink>; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22von+Kriegsheim+A%22">von Kriegsheim A</searchLink>; Edinburgh Cancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Cawthorn+WP%22">Cawthorn WP</searchLink>; Institute for Neuroscience and Cardiovascular Research, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Staines+KA%22">Staines KA</searchLink>; Centre for Lifelong Health, School of Applied Sciences, University of Brighton, Brighton, UK.<br /><searchLink fieldCode="AU" term="%22Stephen+LA%22">Stephen LA</searchLink>; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Farquharson+C%22">Farquharson C</searchLink>; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK. colin.farquharson@roslin.ed.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101608652%22">Bone research</searchLink> [Bone Res] 2026 Jul 15; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Jul 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22West+China+School+of+Stomatology%2C+Sichuan+University%22">West China School of Stomatology, Sichuan University </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101608652 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2095-4700 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220954700%22">20954700 </searchLink><i>NLM ISO Abbreviation: </i>Bone Res <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41413-026-00556-y
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            – D: 15
              M: 07
              Text: 2026 Jul 15
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