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Evolution of KRAS molecular glues: from allele-selective to Pan-RAS and protein-protein interaction modulators.

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Title: Evolution of KRAS molecular glues: from allele-selective to Pan-RAS and protein-protein interaction modulators.
Authors: Xiao XZ; State Key Laboratory of Innovative Immunotherapy, Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China., Wang YJ; State Key Laboratory of Innovative Immunotherapy, Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China.; School·of·Pharmaceutical·Engineering, ·Shenyang·Pharmaceutical·University, Shenyang, 110016, China., Pang XF; Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China., Zhang A; State Key Laboratory of Innovative Immunotherapy, Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China. ao6919zhang@sjtu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jul 15. Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Xiao+XZ%22">Xiao XZ</searchLink>; State Key Laboratory of Innovative Immunotherapy, Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China.<br /><searchLink fieldCode="AU" term="%22Wang+YJ%22">Wang YJ</searchLink>; State Key Laboratory of Innovative Immunotherapy, Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China.; School·of·Pharmaceutical·Engineering, ·Shenyang·Pharmaceutical·University, Shenyang, 110016, China.<br /><searchLink fieldCode="AU" term="%22Pang+XF%22">Pang XF</searchLink>; Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, 200241, China.<br /><searchLink fieldCode="AU" term="%22Zhang+A%22">Zhang A</searchLink>; State Key Laboratory of Innovative Immunotherapy, Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China. ao6919zhang@sjtu.edu.cn.
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        Value: 10.1038/s41401-026-01866-x
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              Text: 2026 Jul 15
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