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Pre-existing retinal inflammation exacerbates gene therapy-associated uveitis in more rapidly progressive retinal degeneration.

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Title: Pre-existing retinal inflammation exacerbates gene therapy-associated uveitis in more rapidly progressive retinal degeneration.
Authors: John MC; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Martinez-Fernandez de la Camara C; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Salman A; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Staurenghi F; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Shamsnajafabadi H; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., McClements ME; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Cehajic-Kapetanovic J; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Bray A; Oxford Biomedica PLC, Oxford, UK., Fischer MD; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Dick AD; Academic Unit of Ophthalmology, University of Bristol, Bristol, UK.; NIHR Biomedical Research Centre of Ophthalmology, Moorfields Eye Hospital, London, UK.; UCL Institute of Ophthalmology, London, UK., MacLaren RE; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Xue K; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Source: Molecular therapy. Advances [Mol Ther Adv] 2025 Dec 26; Vol. 34 (1), pp. 201652. Date of Electronic Publication: 2025 Dec 26 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Country of Publication: United States NLM ID: 9919257804006676 Publication Model: eCollection Cited Medium: Internet ISSN: 3117-387X (Electronic) Linking ISSN: 3117387X NLM ISO Abbreviation: Mol Ther Adv Subsets: PubMed not MEDLINE
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  Data: Pre-existing retinal inflammation exacerbates gene therapy-associated uveitis in more rapidly progressive retinal degeneration.
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  Data: <searchLink fieldCode="AU" term="%22John+MC%22">John MC</searchLink>; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Martinez-Fernandez+de+la+Camara+C%22">Martinez-Fernandez de la Camara C</searchLink>; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Salman+A%22">Salman A</searchLink>; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Staurenghi+F%22">Staurenghi F</searchLink>; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Shamsnajafabadi+H%22">Shamsnajafabadi H</searchLink>; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22McClements+ME%22">McClements ME</searchLink>; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cehajic-Kapetanovic+J%22">Cehajic-Kapetanovic J</searchLink>; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bray+A%22">Bray A</searchLink>; Oxford Biomedica PLC, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Fischer+MD%22">Fischer MD</searchLink>; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dick+AD%22">Dick AD</searchLink>; Academic Unit of Ophthalmology, University of Bristol, Bristol, UK.; NIHR Biomedical Research Centre of Ophthalmology, Moorfields Eye Hospital, London, UK.; UCL Institute of Ophthalmology, London, UK.<br /><searchLink fieldCode="AU" term="%22MacLaren+RE%22">MacLaren RE</searchLink>; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Xue+K%22">Xue K</searchLink>; Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
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  Data: <searchLink fieldCode="JN" term="%229919257804006676%22">Molecular therapy. Advances</searchLink> [Mol Ther Adv] 2025 Dec 26; Vol. 34 (1), pp. 201652. <i>Date of Electronic Publication: </i>2025 Dec 26 (<i>Print Publication: </i>2026).
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