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A novel penicillin-binding protein inhibitor with unprecedented intracellular activity eradicates multiple pathogenic bacteria.

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Title: A novel penicillin-binding protein inhibitor with unprecedented intracellular activity eradicates multiple pathogenic bacteria.
Authors: Guo KX; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Hu HX; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Cheng Z; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Zhang JD; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Zhu FD; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Zhang YL; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Guo CY; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Wu KX; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Cai GH; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Hong HR; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Wan XY; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Yan X; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Chen W; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Liang X; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Duan LC; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Chen HC; The Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of the Development of Veterinary Diagnostic Products, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China., Liu ZF; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.; The Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of the Development of Veterinary Diagnostic Products, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Hongshan Laboratory, Wuhan, China.
Source: PLoS pathogens [PLoS Pathog] 2026 Jul 16; Vol. 22 (7), pp. e1014242. Date of Electronic Publication: 2026 Jul 16 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A novel penicillin-binding protein inhibitor with unprecedented intracellular activity eradicates multiple pathogenic bacteria.
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  Data: <searchLink fieldCode="AU" term="%22Guo+KX%22">Guo KX</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Hu+HX%22">Hu HX</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Cheng+Z%22">Cheng Z</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+JD%22">Zhang JD</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhu+FD%22">Zhu FD</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YL%22">Zhang YL</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Guo+CY%22">Guo CY</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Wu+KX%22">Wu KX</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Cai+GH%22">Cai GH</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Hong+HR%22">Hong HR</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Wan+XY%22">Wan XY</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Yan+X%22">Yan X</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Liang+X%22">Liang X</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Duan+LC%22">Duan LC</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Chen+HC%22">Chen HC</searchLink>; The Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of the Development of Veterinary Diagnostic Products, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Liu+ZF%22">Liu ZF</searchLink>; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.; The Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of the Development of Veterinary Diagnostic Products, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Hongshan Laboratory, Wuhan, China.
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  Data: <searchLink fieldCode="JN" term="%22101238921%22">PLoS pathogens</searchLink> [PLoS Pathog] 2026 Jul 16; Vol. 22 (7), pp. e1014242. <i>Date of Electronic Publication: </i>2026 Jul 16 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101238921 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1553-7374 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215537366%22">15537366 </searchLink><i>NLM ISO Abbreviation: </i>PLoS Pathog <i>Subsets: </i>MEDLINE
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