Structure and evolution-guided design of minimal RNA-guided nucleases.
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| Title: | Structure and evolution-guided design of minimal RNA-guided nucleases. |
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| Authors: | Skopintsev P; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., Esain-Garcia I; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., DeTurk EC; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., Yoon PH; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Zhou Z; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Weiss T; Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA., Kamalu M; Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA., Chamraj A; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Loi KJ; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., Langeberg CJ; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., Boger RS; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.; Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA, CA, USA., Nisonoff H; Center for Computational Biology, University of California Berkeley, Berkeley, CA, USA., Karp HM; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA., Chen LX; Department of Earth and Planetary Science, University of California, Berkeley, CA, USA., Shi H; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., Vohra K; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., Banfield JF; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Earth and Planetary Science, University of California, Berkeley, CA, USA.; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Cate JHD; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Jacobsen SE; Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA.; Howard Hughes Medical Institute (HHMI), University of California at Los Angeles, Los Angeles, CA, USA., Doudna JA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Li Ka Shing Center for Genomic Engineering, University of California, Berkeley, Berkeley, CA, USA.; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. |
| Source: | Science (New York, N.Y.) [Science] 2026 Jul 16; Vol. 393 (6808), pp. 313-318. Date of Electronic Publication: 2026 Jul 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.aed6123 |
