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Structure and evolution-guided design of minimal RNA-guided nucleases.

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Title: Structure and evolution-guided design of minimal RNA-guided nucleases.
Authors: Skopintsev P; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., Esain-Garcia I; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., DeTurk EC; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., Yoon PH; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Zhou Z; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Weiss T; Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA., Kamalu M; Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA., Chamraj A; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Loi KJ; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., Langeberg CJ; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., Boger RS; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.; Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA, CA, USA., Nisonoff H; Center for Computational Biology, University of California Berkeley, Berkeley, CA, USA., Karp HM; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA., Chen LX; Department of Earth and Planetary Science, University of California, Berkeley, CA, USA., Shi H; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., Vohra K; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA., Banfield JF; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Earth and Planetary Science, University of California, Berkeley, CA, USA.; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia., Cate JHD; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Jacobsen SE; Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA.; Howard Hughes Medical Institute (HHMI), University of California at Los Angeles, Los Angeles, CA, USA., Doudna JA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Li Ka Shing Center for Genomic Engineering, University of California, Berkeley, Berkeley, CA, USA.; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Source: Science (New York, N.Y.) [Science] 2026 Jul 16; Vol. 393 (6808), pp. 313-318. Date of Electronic Publication: 2026 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Skopintsev+P%22">Skopintsev P</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Esain-Garcia+I%22">Esain-Garcia I</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22DeTurk+EC%22">DeTurk EC</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yoon+PH%22">Yoon PH</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+T%22">Weiss T</searchLink>; Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kamalu+M%22">Kamalu M</searchLink>; Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chamraj+A%22">Chamraj A</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Loi+KJ%22">Loi KJ</searchLink>; 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Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+LX%22">Chen LX</searchLink>; Department of Earth and Planetary Science, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shi+H%22">Shi H</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vohra+K%22">Vohra K</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Banfield+JF%22">Banfield JF</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Earth and Planetary Science, University of California, Berkeley, CA, USA.; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Cate+JHD%22">Cate JHD</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jacobsen+SE%22">Jacobsen SE</searchLink>; Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA.; Howard Hughes Medical Institute (HHMI), University of California at Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Doudna+JA%22">Doudna JA</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Li Ka Shing Center for Genomic Engineering, University of California, Berkeley, Berkeley, CA, USA.; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
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