A novel STAT4 gain-of-function variant defines a monogenic form of juvenile-onset systemic lupus erythematosus.

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Title: A novel STAT4 gain-of-function variant defines a monogenic form of juvenile-onset systemic lupus erythematosus.
Authors: Sormani J; Internal Medicine Department, Lyon-Sud Hospital, Hospices Civils de Lyon, Oullins-Pierre-Bénite, Auvergne-Rhône-Alpes, France; Inserm U1111, CNRS, UMR5308, ENS of Lyon, Centre International de Recherche en Infectiologie (CIRI), Claude Bernard University Lyon 1, Lyon, France., Chenel A; Inserm U1111, CNRS, UMR5308, ENS of Lyon, Centre International de Recherche en Infectiologie (CIRI), Claude Bernard University Lyon 1, Lyon, France., Conti EA; Inserm U1111, CNRS, UMR5308, ENS of Lyon, Centre International de Recherche en Infectiologie (CIRI), Claude Bernard University Lyon 1, Lyon, France; University of Milan, Milan, Italy., Doutriaux C; Inserm U1111, CNRS, UMR5308, ENS of Lyon, Centre International de Recherche en Infectiologie (CIRI), Claude Bernard University Lyon 1, Lyon, France., Jamilloux Y; Inserm U1111, CNRS, UMR5308, ENS of Lyon, Centre International de Recherche en Infectiologie (CIRI), Claude Bernard University Lyon 1, Lyon, France; Internal Medicine Department, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon, Auvergne-Rhône-Alpes, France., Henry T; Inserm U1111, CNRS, UMR5308, ENS of Lyon, Centre International de Recherche en Infectiologie (CIRI), Claude Bernard University Lyon 1, Lyon, France., Cognard J; Inserm U1111, CNRS, UMR5308, ENS of Lyon, Centre International de Recherche en Infectiologie (CIRI), Claude Bernard University Lyon 1, Lyon, France; National Referee Centre for Pediatric-Onset Rheumatism and Autoimmune Diseases, Hospices Civils de Lyon, Pediatric Nephrology, Rheumatology, Dermatology Unit, Mother and Children University Hospital, Bron, Auvergne-Rhône-Alpes, France., Walzer T; Inserm U1111, CNRS, UMR5308, ENS of Lyon, Centre International de Recherche en Infectiologie (CIRI), Claude Bernard University Lyon 1, Lyon, France., Tusseau M; Inserm U1111, CNRS, UMR5308, ENS of Lyon, Centre International de Recherche en Infectiologie (CIRI), Claude Bernard University Lyon 1, Lyon, France; Medical Genetics Department, Hospices Civils de Lyon, Bron, Auvergne-Rhône-Alpes, France., Chan OM; Department of Paediatrics, Prince of Wales Hospital, Hong Kong., Kwong HC; Department of Paediatrics, Prince of Wales Hospital, Hong Kong., Li AM; Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong., Chan KCC; Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong., Tang NLS; Department of Chemical Pathology, Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong., Chu WCW; Department of Imaging & Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong., Au EYL; Division of Clinical Immunology, Department of Pathology, Queen Mary Hospital, Hong Kong., Lam K; Division of Clinical Immunology, Department of Pathology, Queen Mary Hospital, Hong Kong., Cheong KN; Division of Immunology, Rheumatology and Allergy, Paediatric and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong., Mathieu AL; Inserm U1111, CNRS, UMR5308, ENS of Lyon, Centre International de Recherche en Infectiologie (CIRI), Claude Bernard University Lyon 1, Lyon, France., Ho ACH; Department of Paediatrics, Prince of Wales Hospital, Hong Kong., Belot A; Inserm U1111, CNRS, UMR5308, ENS of Lyon, Centre International de Recherche en Infectiologie (CIRI), Claude Bernard University Lyon 1, Lyon, France; National Referee Centre for Pediatric-Onset Rheumatism and Autoimmune Diseases, Hospices Civils de Lyon, Pediatric Nephrology, Rheumatology, Dermatology Unit, Mother and Children University Hospital, Bron, Auvergne-Rhône-Alpes, France. Electronic address: alexandre.belot@chu-lyon.fr.
Source: Annals of the rheumatic diseases [Ann Rheum Dis] 2026 Jul 16. Date of Electronic Publication: 2026 Jul 16.
Publication Type: Letter
Journal Info: Publisher: BMJ Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1468-2060
DOI:10.1016/j.ard.2026.06.023