In vivo multimodal PET/MRI imaging and plasma biomarkers implicate glymphatic dysfunction linking neuroinflammation to tau pathology in the early Alzheimer's disease continuum.

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Title: In vivo multimodal PET/MRI imaging and plasma biomarkers implicate glymphatic dysfunction linking neuroinflammation to tau pathology in the early Alzheimer's disease continuum.
Authors: Xu X; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Liu D; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Sun X; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China., Yang K; Department of Mathematics, Southeast University, Nanjing, 210096, China., Lv P; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Lu J; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Ruan W; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China., Xia X; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China., Chen J; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China., Chen Y; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China., Wang H; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Wu X; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Ge D; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Yang B; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China., Wan M; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China., Liang H; The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, 241000, China., Lan X; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. LXL730724@hotmail.com.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China. LXL730724@hotmail.com.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China. LXL730724@hotmail.com., Gai Y; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. gykmail@hust.edu.cn.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China. gykmail@hust.edu.cn.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China. gykmail@hust.edu.cn., Zhang B; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China. zhangbing_nanjing@nju.edu.cn.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, 210008, China. zhangbing_nanjing@nju.edu.cn.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China. zhangbing_nanjing@nju.edu.cn.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China. zhangbing_nanjing@nju.edu.cn.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China. zhangbing_nanjing@nju.edu.cn.
Source: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2026 Jul 17. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Berlin Country of Publication: Germany NLM ID: 101140988 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-7089 (Electronic) Linking ISSN: 16197070 NLM ISO Abbreviation: Eur J Nucl Med Mol Imaging Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1619-7089
DOI:10.1007/s00259-026-08067-y