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In vivo multimodal PET/MRI imaging and plasma biomarkers implicate glymphatic dysfunction linking neuroinflammation to tau pathology in the early Alzheimer's disease continuum.

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Title: In vivo multimodal PET/MRI imaging and plasma biomarkers implicate glymphatic dysfunction linking neuroinflammation to tau pathology in the early Alzheimer's disease continuum.
Authors: Xu X; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Liu D; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Sun X; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China., Yang K; Department of Mathematics, Southeast University, Nanjing, 210096, China., Lv P; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Lu J; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Ruan W; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China., Xia X; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China., Chen J; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China., Chen Y; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China., Wang H; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Wu X; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Ge D; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China., Yang B; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China., Wan M; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China., Liang H; The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, 241000, China., Lan X; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. LXL730724@hotmail.com.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China. LXL730724@hotmail.com.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China. LXL730724@hotmail.com., Gai Y; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. gykmail@hust.edu.cn.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China. gykmail@hust.edu.cn.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China. gykmail@hust.edu.cn., Zhang B; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China. zhangbing_nanjing@nju.edu.cn.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, 210008, China. zhangbing_nanjing@nju.edu.cn.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China. zhangbing_nanjing@nju.edu.cn.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China. zhangbing_nanjing@nju.edu.cn.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China. zhangbing_nanjing@nju.edu.cn.
Source: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2026 Jul 17. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Berlin Country of Publication: Germany NLM ID: 101140988 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-7089 (Electronic) Linking ISSN: 16197070 NLM ISO Abbreviation: Eur J Nucl Med Mol Imaging Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In vivo multimodal PET/MRI imaging and plasma biomarkers implicate glymphatic dysfunction linking neuroinflammation to tau pathology in the early Alzheimer's disease continuum.
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  Data: <searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China.<br /><searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; Department of Mathematics, Southeast University, Nanjing, 210096, China.<br /><searchLink fieldCode="AU" term="%22Lv+P%22">Lv P</searchLink>; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.<br /><searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.<br /><searchLink fieldCode="AU" term="%22Ruan+W%22">Ruan W</searchLink>; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China.<br /><searchLink fieldCode="AU" term="%22Xia+X%22">Xia X</searchLink>; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.<br /><searchLink fieldCode="AU" term="%22Ge+D%22">Ge D</searchLink>; Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.; Institute of Medical Imaging and Artificial Intelligence, Department of Psychology, Institute of Medical Imaging and Artificial Intelligence, Institute of Brain Science, Institute of Brain-Machine Interface, Nanjing University, Nanjing, 210008, China.; Department of Radiology, Medical Imaging Center, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.<br /><searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China.<br /><searchLink fieldCode="AU" term="%22Wan+M%22">Wan M</searchLink>; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China.<br /><searchLink fieldCode="AU" term="%22Liang+H%22">Liang H</searchLink>; The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, 241000, China.<br /><searchLink fieldCode="AU" term="%22Lan+X%22">Lan X</searchLink>; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. LXL730724@hotmail.com.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China. LXL730724@hotmail.com.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, 430022, China. 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      – TitleFull: In vivo multimodal PET/MRI imaging and plasma biomarkers implicate glymphatic dysfunction linking neuroinflammation to tau pathology in the early Alzheimer's disease continuum.
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              Text: 2026 Jul 17
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