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Coordinated expansion of CD163+ monocytes and immature CD177+ neutrophils marks severe neurotoxicity after CD19 CAR T cell therapy.

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Title: Coordinated expansion of CD163+ monocytes and immature CD177+ neutrophils marks severe neurotoxicity after CD19 CAR T cell therapy.
Authors: Chour T; Department of Laboratory Medicine and Pathology, University of Washington.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center., Poole N; Department of Laboratory Medicine and Pathology, University of Washington.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center.; Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle Children's Hospital, University of Washington, Seattle, Washington., MacMillan HR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center., Burleigh K; Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle Children's Hospital, University of Washington, Seattle, Washington., Glass DR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center., Liang EC; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA., Basom R; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington., Webb-Robertson BM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington., Stratton K; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington., Gratz D; Fred Hutch Innovation Lab, Fred Hutchinson Cancer Center, Seattle, WA, USA., Long AN; Fred Hutch Innovation Lab, Fred Hutchinson Cancer Center, Seattle, WA, USA., Elz AE; Fred Hutch Innovation Lab, Fred Hutchinson Cancer Center, Seattle, WA, USA., Huang JJ; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA., Hirayama AV; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA.; Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Center, Seattle, Washington.; Department of Medicine, University of Washington, Seattle, Washington., Riddell SR; Department of Medicine, University of Washington, Seattle, Washington.; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Gauthier J; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA.; Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Center, Seattle, Washington.; Department of Medicine, University of Washington, Seattle, Washington., Gustafson HH; Department of Laboratory Medicine and Pathology, University of Washington.; Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle Children's Hospital, University of Washington, Seattle, Washington.; Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington., Newell EW; Department of Laboratory Medicine and Pathology, University of Washington.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center.; Fred Hutch Innovation Lab, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Center, Seattle, Washington., Simon S; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jul 09. Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Coordinated expansion of CD163<subscript>+</subscript> monocytes and immature CD177<subscript>+</subscript> neutrophils marks severe neurotoxicity after CD19 CAR T cell therapy.
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  Data: <searchLink fieldCode="AU" term="%22Chour+T%22">Chour T</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center.<br /><searchLink fieldCode="AU" term="%22Poole+N%22">Poole N</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center.; Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle Children's Hospital, University of Washington, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22MacMillan+HR%22">MacMillan HR</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center.<br /><searchLink fieldCode="AU" term="%22Burleigh+K%22">Burleigh K</searchLink>; Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle Children's Hospital, University of Washington, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Glass+DR%22">Glass DR</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center.<br /><searchLink fieldCode="AU" term="%22Liang+EC%22">Liang EC</searchLink>; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Basom+R%22">Basom R</searchLink>; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Webb-Robertson+BM%22">Webb-Robertson BM</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington.<br /><searchLink fieldCode="AU" term="%22Stratton+K%22">Stratton K</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington.<br /><searchLink fieldCode="AU" term="%22Gratz+D%22">Gratz D</searchLink>; Fred Hutch Innovation Lab, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Long+AN%22">Long AN</searchLink>; Fred Hutch Innovation Lab, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Elz+AE%22">Elz AE</searchLink>; Fred Hutch Innovation Lab, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+JJ%22">Huang JJ</searchLink>; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Hirayama+AV%22">Hirayama AV</searchLink>; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA.; Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Center, Seattle, Washington.; Department of Medicine, University of Washington, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Riddell+SR%22">Riddell SR</searchLink>; Department of Medicine, University of Washington, Seattle, Washington.; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Gauthier+J%22">Gauthier J</searchLink>; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA.; Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Center, Seattle, Washington.; Department of Medicine, University of Washington, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Gustafson+HH%22">Gustafson HH</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington.; Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle Children's Hospital, University of Washington, Seattle, Washington.; Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Newell+EW%22">Newell EW</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center.; Fred Hutch Innovation Lab, Fred Hutchinson Cancer Center, Seattle, WA, USA.; Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Center, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Simon+S%22">Simon S</searchLink>; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Jul 09. <i>Date of Electronic Publication: </i>2026 Jul 09.
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        Value: 10.64898/2026.07.07.737099
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              Text: 2026 Jul 09
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