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Loss of ST8Sia6 mediated α-2,8-linked di-sialylation enhances T cell-dependent antibody responses and promotes autoimmunity in aged mice.

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Title: Loss of ST8Sia6 mediated α-2,8-linked di-sialylation enhances T cell-dependent antibody responses and promotes autoimmunity in aged mice.
Authors: Brüchert R; Division of Genetics, Department of Biology, FAU University of Erlangen-Nürnberg, Erlangen, Germany., Hinzpeter-Schmidt M; Division of Genetics, Department of Biology, FAU University of Erlangen-Nürnberg, Erlangen, Germany., Röder B; Division of Genetics, Department of Biology, FAU University of Erlangen-Nürnberg, Erlangen, Germany., Krause M; Division of Genetics, Department of Biology, FAU University of Erlangen-Nürnberg, Erlangen, Germany., Brey S; Division of Genetics, Department of Biology, FAU University of Erlangen-Nürnberg, Erlangen, Germany., Winkler TH; Division of Genetics, Department of Biology, FAU University of Erlangen-Nürnberg, Erlangen, Germany., Buettner FFR; Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.; Proteomics, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany., Mühlenhoff M; Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany., Nitschke L; Division of Genetics, Department of Biology, FAU University of Erlangen-Nürnberg, Erlangen, Germany.
Source: Frontiers in immunology [Front Immunol] 2026 Jul 02; Vol. 17, pp. 1874115. Date of Electronic Publication: 2026 Jul 02 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2026.1874115