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Placental DNA methylation captures shared and trait-specific genetic susceptibility across complex health conditions.

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Title: Placental DNA methylation captures shared and trait-specific genetic susceptibility across complex health conditions.
Authors: Cilleros-Portet A; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain., González-Moro I; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain., Sadikki H; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marí S; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain., Everson TM; Gangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA., Hernangómez-Laderas A; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain., Broséus L; Université Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l'Avancée des Biosciences (IAB), Team of Environmental Epidemiology Applied to Development and Respiratory Health, 38000 Grenoble, France., Tost J; Laboratory for Epigenetics & Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, Université Paris - Saclay, Evry, France., Cosín-Tomàs M; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Barcelona InTerdisciplinary research group on plAnetary heaLth (BITAL), Faculty of Health Sciences, Universitat Oberta de Catalunya (UOC), Barcelona, Spain., Groleau M; Department of Biology, Université de Sherbrooke, Sherbrooke, QC, Canada., Czamara D; Department Genes and Environment, Max-Planck-Institute of Psychiatry, Germany., Lozano M; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, Universitat de València, Valencia, Spain.; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-University of València, Valencia, Spain., Hao K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tuhkanen J; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland., Fallin MD; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA., Schmidt RJ; Department of Public Health Sciences, University of California Davis, Davis, CA, USA., Breeze CE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Deleuze JF; Laboratory for Functional Genomics, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, Université Paris - Saclay, Evry, France., Aguilar-Lacasaña S; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Jacques PE; Department of Biology, Université de Sherbrooke, Sherbrooke, QC, Canada.; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Sherbrooke, QC, Canada., Hytti S; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland., Irizar A; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Department of Preventive Medicine and Public Health, Biogipuzkoa Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain., Lahti-Pulkkinen M; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland., Bakulski KM; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Dou J; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Lahti J; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland., Vrijheid M; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Räikkönen K; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland., Hivert MF; Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada., Sunyer J; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Heude B; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Lifecourse Epidemiology, OPPaLE, F-75004 Paris, France., Lepeule J; Université Grenoble Alpes, INSERM U1209, CNRS UMR 5309. Institut pour l'Avancée des Biosciences (IAB), Team of Environmental Epidemiology Applied to Development and Respiratory Health, 38000 GRENOBLE, France., London SJ; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA., Chen J; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bustamante M; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Marsit CJ; Gangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA., Bilbao JR; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain., Lesseur C; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fernandez-Jimenez N; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Jul 09. Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Placental DNA methylation captures shared and trait-specific genetic susceptibility across complex health conditions.
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  Data: <searchLink fieldCode="AU" term="%22Cilleros-Portet+A%22">Cilleros-Portet A</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.<br /><searchLink fieldCode="AU" term="%22González-Moro+I%22">González-Moro I</searchLink>; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.<br /><searchLink fieldCode="AU" term="%22Sadikki+H%22">Sadikki H</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Marí+S%22">Marí S</searchLink>; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.<br /><searchLink fieldCode="AU" term="%22Everson+TM%22">Everson TM</searchLink>; Gangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Hernangómez-Laderas+A%22">Hernangómez-Laderas A</searchLink>; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.<br /><searchLink fieldCode="AU" term="%22Broséus+L%22">Broséus L</searchLink>; Université Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l'Avancée des Biosciences (IAB), Team of Environmental Epidemiology Applied to Development and Respiratory Health, 38000 Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Tost+J%22">Tost J</searchLink>; Laboratory for Epigenetics & Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, Université Paris - Saclay, Evry, France.<br /><searchLink fieldCode="AU" term="%22Cosín-Tomàs+M%22">Cosín-Tomàs M</searchLink>; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Barcelona InTerdisciplinary research group on plAnetary heaLth (BITAL), Faculty of Health Sciences, Universitat Oberta de Catalunya (UOC), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Groleau+M%22">Groleau M</searchLink>; Department of Biology, Université de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Czamara+D%22">Czamara D</searchLink>; Department Genes and Environment, Max-Planck-Institute of Psychiatry, Germany.<br /><searchLink fieldCode="AU" term="%22Lozano+M%22">Lozano M</searchLink>; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, Universitat de València, Valencia, Spain.; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-University of València, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Hao+K%22">Hao K</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tuhkanen+J%22">Tuhkanen J</searchLink>; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Fallin+MD%22">Fallin MD</searchLink>; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Schmidt+RJ%22">Schmidt RJ</searchLink>; Department of Public Health Sciences, University of California Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Breeze+CE%22">Breeze CE</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Deleuze+JF%22">Deleuze JF</searchLink>; Laboratory for Functional Genomics, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, Université Paris - Saclay, Evry, France.<br /><searchLink fieldCode="AU" term="%22Aguilar-Lacasaña+S%22">Aguilar-Lacasaña S</searchLink>; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Jacques+PE%22">Jacques PE</searchLink>; Department of Biology, Université de Sherbrooke, Sherbrooke, QC, Canada.; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Hytti+S%22">Hytti S</searchLink>; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Irizar+A%22">Irizar A</searchLink>; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Department of Preventive Medicine and Public Health, Biogipuzkoa Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.<br /><searchLink fieldCode="AU" term="%22Lahti-Pulkkinen+M%22">Lahti-Pulkkinen M</searchLink>; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Bakulski+KM%22">Bakulski KM</searchLink>; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Dou+J%22">Dou J</searchLink>; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Lahti+J%22">Lahti J</searchLink>; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Vrijheid+M%22">Vrijheid M</searchLink>; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Räikkönen+K%22">Räikkönen K</searchLink>; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Hivert+MF%22">Hivert MF</searchLink>; Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Sunyer+J%22">Sunyer J</searchLink>; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Heude+B%22">Heude B</searchLink>; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Lifecourse Epidemiology, OPPaLE, F-75004 Paris, France.<br /><searchLink fieldCode="AU" term="%22Lepeule+J%22">Lepeule J</searchLink>; Université Grenoble Alpes, INSERM U1209, CNRS UMR 5309. Institut pour l'Avancée des Biosciences (IAB), Team of Environmental Epidemiology Applied to Development and Respiratory Health, 38000 GRENOBLE, France.<br /><searchLink fieldCode="AU" term="%22London+SJ%22">London SJ</searchLink>; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bustamante+M%22">Bustamante M</searchLink>; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Marsit+CJ%22">Marsit CJ</searchLink>; Gangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Bilbao+JR%22">Bilbao JR</searchLink>; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lesseur+C%22">Lesseur C</searchLink>; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fernandez-Jimenez+N%22">Fernandez-Jimenez N</searchLink>; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.
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