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Dapagliflozin does not impair LDL catabolism and induces a shift towards a closer to normal VLDL1/VLDL2 catabolism in individuals with type 2 diabetes: a randomised in vivo kinetic study.

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Title: Dapagliflozin does not impair LDL catabolism and induces a shift towards a closer to normal VLDL1/VLDL2 catabolism in individuals with type 2 diabetes: a randomised in vivo kinetic study.
Authors: Vergès B; Université de Bourgogne Europe, Inserm UMR1231 Center for Translational and Molecular Medicine (CTM), Team Pathophysiology of Dyslipidemia (PADYS), Dijon, France. bruno.verges@chu-dijon.fr.; Université de Bourgogne Europe, CHU Dijon Bourgogne, Department of Endocrinology/Diabetology, Dijon, France. bruno.verges@chu-dijon.fr., Rouland A; Université de Bourgogne Europe, Inserm UMR1231 Center for Translational and Molecular Medicine (CTM), Team Pathophysiology of Dyslipidemia (PADYS), Dijon, France.; Université de Bourgogne Europe, CHU Dijon Bourgogne, Department of Endocrinology/Diabetology, Dijon, France., Bouillet B; Université de Bourgogne Europe, Inserm UMR1231 Center for Translational and Molecular Medicine (CTM), Team Pathophysiology of Dyslipidemia (PADYS), Dijon, France.; Université de Bourgogne Europe, CHU Dijon Bourgogne, Department of Endocrinology/Diabetology, Dijon, France., Pais de Barros JP; Université Bourgogne Europe, Inserm, UMS 058 BioSanD, DiviOmics, Dijon, France., Fourmont C; Université de Bourgogne Europe, CHU Dijon Bourgogne, Department of Endocrinology/Diabetology, Dijon, France., Buffier P; Université de Bourgogne Europe, CHU Dijon Bourgogne, Department of Endocrinology/Diabetology, Dijon, France., Jourdan T; Université de Bourgogne Europe, Inserm UMR1231 Center for Translational and Molecular Medicine (CTM), Team Pathophysiology of Dyslipidemia (PADYS), Dijon, France., Vergas V; Université Bourgogne Europe, Inserm, UMS 058 BioSanD, DiviOmics, Dijon, France., Duvillard L; Université de Bourgogne Europe, Inserm UMR1231 Center for Translational and Molecular Medicine (CTM), Team Pathophysiology of Dyslipidemia (PADYS), Dijon, France.; Université de Bourgogne Europe, CHU Dijon Bourgogne, Department of Biochemistry, Dijon, France.
Source: Diabetologia [Diabetologia] 2026 Jul 17. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0428
DOI:10.1007/s00125-026-06810-6