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Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities.

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Title: Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities.
Authors: Banerjee C; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India., Singh RK; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India., Choudhary D; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India., Khan MN; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India., Maurya PK; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India., Khan Z; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India., Mehan S; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India. sidh.mehan@gmail.com.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India. sidh.mehan@gmail.com., Samant R; Chief Scientific Officer, Celagenex Research, Thane, Mumbai, India., Tongra M; Chief Scientific Officer, Celagenex Research, Thane, Mumbai, India.
Source: Immunologic research [Immunol Res] 2026 Jul 17; Vol. 74 (1). Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article; Review
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8611087 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0755 (Electronic) Linking ISSN: 0257277X NLM ISO Abbreviation: Immunol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1559-0755
DOI:10.1007/s12026-026-09808-9