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A neurocutaneous NaV1.8 channelopathy underlies a genetic subtype of primary idiopathic hyperhidrosis.

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Title: A neurocutaneous NaV1.8 channelopathy underlies a genetic subtype of primary idiopathic hyperhidrosis.
Authors: Yamauchi S; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Esophageal and Gastroenterological Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan., Vander Cruyssen J; Molecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Experimental Pharmacology, Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Jette, Belgium., Cervellera M; Tissue Engineering and Biomaterials Group, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Wohler E; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., De Waele J; Molecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Experimental Pharmacology, Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Jette, Belgium., Lammens M; Molecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Experimental Pharmacology, Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Jette, Belgium., Boehm C; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sobreira NL; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Blevins C; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ecoff K; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mei Y; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Theys M; Molecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Shoyombo I; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Shishikura M; Institute of Science, Tokyo, Japan., Yi H; Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA., Rodgers K; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lee B; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Khan H; Department of Vascular Surgery, Deborah Heart and Lung Center, Brown Mills, NJ, USA., Gurau A; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Nizam W; Department of Surgery, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA., Shirodkar S; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kim C; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Choi J; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Coleman D; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Dorman B; Chicago College of Osteopathic Medicine, Downers Grove, IL, USA., Iwasawa T; Institute of Life Innovation Studies, Toyo University, Tokyo, Japan., Kang JU; Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA., Heremans Y; Visual and Spatial Tissue Analysis (VSTA) core facility and Beta Cell Neogenesis Research Group (BENE), Genetics Reproduction and Development (GRAD), Faculty of Medicine and Pharmaceutical Sciences, Vrije Universiteit Brussel, Jette, Belgium., Orita H; Department of Esophageal and Gastroenterological Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan., Fukunaga T; Department of Esophageal and Gastroenterological Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan., Van Petegem F; Department of Biochemistry and Molecular Biology, Life Sciences Centre, University of British Columbia, Vancouver, BC, Canada., Baylin SB; Cancer Genetics and Epigenetics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA., Barth AS; Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chung TH; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Rowe PC; Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Treisman G; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ha J; Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Dmitriev RI; Tissue Engineering and Biomaterials Group, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Valle D; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bosmans F; Molecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Experimental Pharmacology, Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Jette, Belgium.; Center for Neurosciences (C4N), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Belgium., Brock MV; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Source: Science advances [Sci Adv] 2026 Jul 17; Vol. 12 (29), pp. eaed3221. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: A neurocutaneous Na<subscript>V</subscript>1.8 channelopathy underlies a genetic subtype of primary idiopathic hyperhidrosis.
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McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22De+Waele+J%22">De Waele J</searchLink>; Molecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Experimental Pharmacology, Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Jette, Belgium.<br /><searchLink fieldCode="AU" term="%22Lammens+M%22">Lammens M</searchLink>; Molecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Experimental Pharmacology, Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Jette, Belgium.<br /><searchLink fieldCode="AU" term="%22Boehm+C%22">Boehm C</searchLink>; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sobreira+NL%22">Sobreira NL</searchLink>; 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Chicago College of Osteopathic Medicine, Downers Grove, IL, USA.<br /><searchLink fieldCode="AU" term="%22Iwasawa+T%22">Iwasawa T</searchLink>; Institute of Life Innovation Studies, Toyo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kang+JU%22">Kang JU</searchLink>; Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Heremans+Y%22">Heremans Y</searchLink>; Visual and Spatial Tissue Analysis (VSTA) core facility and Beta Cell Neogenesis Research Group (BENE), Genetics Reproduction and Development (GRAD), Faculty of Medicine and Pharmaceutical Sciences, Vrije Universiteit Brussel, Jette, Belgium.<br /><searchLink fieldCode="AU" term="%22Orita+H%22">Orita H</searchLink>; Department of Esophageal and Gastroenterological Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Fukunaga+T%22">Fukunaga T</searchLink>; Department of Esophageal and Gastroenterological Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Van+Petegem+F%22">Van Petegem F</searchLink>; Department of Biochemistry and Molecular Biology, Life Sciences Centre, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Baylin+SB%22">Baylin SB</searchLink>; Cancer Genetics and Epigenetics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Barth+AS%22">Barth AS</searchLink>; Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chung+TH%22">Chung TH</searchLink>; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rowe+PC%22">Rowe PC</searchLink>; Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Treisman+G%22">Treisman G</searchLink>; 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Center for Neurosciences (C4N), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Belgium.<br /><searchLink fieldCode="AU" term="%22Brock+MV%22">Brock MV</searchLink>; Department of Surgery, The Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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