Synthesis, in vitro and in silico studies of transition metal complexes of chrysin with potent anticancer activity via GSK3β phosphorylation, modulation of p38 MAPK pathway and HDAC8 inhibition.

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Title: Synthesis, in vitro and in silico studies of transition metal complexes of chrysin with potent anticancer activity via GSK3β phosphorylation, modulation of p38 MAPK pathway and HDAC8 inhibition.
Authors: Break MKB; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia; Medical and Diagnostic Research Centre, University of Ha'il, Ha'il 55473, Saudi Arabia. Electronic address: m.binbreak@uoh.edu.sa., Hossan MS; University of Wisconsin-Madison, Madison, WI, USA., Ansari SA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O Box 2457, Riyadh 11451, Saudi Arabia., Faisal A; Department of Life Sciences, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences (LUMS), Lahore, Pakistan., Katamesh AA; Department of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia., Khoo TJ; School of Pharmacy, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Selangor 43500, Malaysia., Nawaz M; Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia., Anwar S; Department of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia., Albadari N; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia., Elariny HA; Department of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia., Alsultan IM; Department of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia., Alghamdi OA; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia., Alrshidi MA; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia., Musa M; School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK., Bradshaw TD; School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Source: Bioorganic chemistry [Bioorg Chem] 2026 Jul 16; Vol. 180, pp. 110253. Date of Electronic Publication: 2026 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1090-2120
DOI:10.1016/j.bioorg.2026.110253