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Synthesis, in vitro and in silico studies of transition metal complexes of chrysin with potent anticancer activity via GSK3β phosphorylation, modulation of p38 MAPK pathway and HDAC8 inhibition.

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Title: Synthesis, in vitro and in silico studies of transition metal complexes of chrysin with potent anticancer activity via GSK3β phosphorylation, modulation of p38 MAPK pathway and HDAC8 inhibition.
Authors: Break MKB; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia; Medical and Diagnostic Research Centre, University of Ha'il, Ha'il 55473, Saudi Arabia. Electronic address: m.binbreak@uoh.edu.sa., Hossan MS; University of Wisconsin-Madison, Madison, WI, USA., Ansari SA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O Box 2457, Riyadh 11451, Saudi Arabia., Faisal A; Department of Life Sciences, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences (LUMS), Lahore, Pakistan., Katamesh AA; Department of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia., Khoo TJ; School of Pharmacy, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Selangor 43500, Malaysia., Nawaz M; Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia., Anwar S; Department of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia., Albadari N; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia., Elariny HA; Department of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia., Alsultan IM; Department of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia., Alghamdi OA; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia., Alrshidi MA; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia., Musa M; School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK., Bradshaw TD; School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Source: Bioorganic chemistry [Bioorg Chem] 2026 Jul 16; Vol. 180, pp. 110253. Date of Electronic Publication: 2026 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Synthesis, in vitro and in silico studies of transition metal complexes of chrysin with potent anticancer activity via GSK3β phosphorylation, modulation of p38 MAPK pathway and HDAC8 inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Break+MKB%22">Break MKB</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia; Medical and Diagnostic Research Centre, University of Ha'il, Ha'il 55473, Saudi Arabia. Electronic address: m.binbreak@uoh.edu.sa.<br /><searchLink fieldCode="AU" term="%22Hossan+MS%22">Hossan MS</searchLink>; University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Ansari+SA%22">Ansari SA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O Box 2457, Riyadh 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Faisal+A%22">Faisal A</searchLink>; Department of Life Sciences, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences (LUMS), Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Katamesh+AA%22">Katamesh AA</searchLink>; Department of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Khoo+TJ%22">Khoo TJ</searchLink>; School of Pharmacy, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Selangor 43500, Malaysia.<br /><searchLink fieldCode="AU" term="%22Nawaz+M%22">Nawaz M</searchLink>; Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Anwar+S%22">Anwar S</searchLink>; Department of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Albadari+N%22">Albadari N</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Elariny+HA%22">Elariny HA</searchLink>; Department of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alsultan+IM%22">Alsultan IM</searchLink>; Department of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alghamdi+OA%22">Alghamdi OA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alrshidi+MA%22">Alrshidi MA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Musa+M%22">Musa M</searchLink>; School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.<br /><searchLink fieldCode="AU" term="%22Bradshaw+TD%22">Bradshaw TD</searchLink>; School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
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              Text: 2026 Jul 16
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