Disruption of CDK4/6-RARα-NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy.

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Title: Disruption of CDK4/6-RARα-NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy.
Authors: Wang B; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningent, the Netherlands., Piccolantonio A; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningent, the Netherlands., Altulea A; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningent, the Netherlands., Huang M; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningent, the Netherlands., Joshi T; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningent, the Netherlands., Pagliarin F; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningent, the Netherlands., Di Palma M; Department of Biomedical Sciences, University of Padova, Padova, Italy., Lin Y; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningent, the Netherlands., Mackedenski S; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningent, the Netherlands., Ustyantsev K; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningent, the Netherlands., Jager C; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningent, the Netherlands., Berezikov E; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningent, the Netherlands., Demaria M; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningent, the Netherlands. m.demaria@umcg.nl.
Source: Nature aging [Nat Aging] 2026 Jul 17. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-8465
DOI:10.1038/s43587-026-01168-1