Evolution, structure and function of the putative biosynthetic gene cluster of the fungal secondary metabolite myriocin, a potent inhibitory sphingolipid.

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Title: Evolution, structure and function of the putative biosynthetic gene cluster of the fungal secondary metabolite myriocin, a potent inhibitory sphingolipid.
Authors: Rutter B; School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK., Herrera MA; School of Chemistry, University of Edinburgh, Edinburgh, UK., Perez Ortiz G; School of Chemistry, University of Edinburgh, Edinburgh, UK., Greco C; Department of Biosciences, Swansea University, Swansea, UK., Ashley B; School of Chemistry, University of Edinburgh, Edinburgh, UK., Deng H; Department of Chemistry, School of Natural & Computing Sciences, University of Aberdeen, Aberdeen, UK., Hay A; School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK., Bedford C; Medical Research Council Centre for Medical Mycology at the University of Exeter, Exeter, UK., Wenzel M; Centre for Genome-Enabled Biology & Medicine, University of Aberdeen, Aberdeen, UK.; School of Biological Sciences, University of Aberdeen, Aberdeen, UK., Mondo S; US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Konkel Z; Department of Plant Pathology, The Ohio State University, Columbus, USA., Slot JC; Department of Plant Pathology, The Ohio State University, Columbus, USA., Ma Q; Medical Research Council Centre for Medical Mycology at the University of Exeter, Exeter, UK., Helmstetter N; Medical Research Council Centre for Medical Mycology at the University of Exeter, Exeter, UK., Farrer RA; Medical Research Council Centre for Medical Mycology at the University of Exeter, Exeter, UK., Campopiano DJ; School of Chemistry, University of Edinburgh, Edinburgh, UK., Brand AC; School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK. a.brand@exeter.ac.uk.; Medical Research Council Centre for Medical Mycology at the University of Exeter, Exeter, UK. a.brand@exeter.ac.uk.; Living Systems Institute, University of Exeter, Exeter, UK. a.brand@exeter.ac.uk.
Source: Communications biology [Commun Biol] 2026 Jul 17. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2399-3642
DOI:10.1038/s42003-026-10708-9