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Plasma metabolomic signatures of heterogeneous multimorbidity trajectories in ageing: a population-based cohort study.

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Title: Plasma metabolomic signatures of heterogeneous multimorbidity trajectories in ageing: a population-based cohort study.
Authors: Toki R; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. rtoki@keio.jp., Iba C; Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Omoto Y; Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., Matsumoto M; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan., Iida M; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan., Edagawa S; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan., Harada S; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan., Hirata A; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan., Miyagawa N; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan., Miyake A; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan., Hirayama A; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan., Sugimoto M; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan., Sato A; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan., Amano K; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan., Soga T; Human Biology-Microbiome-Quantum Research Center, Keio University, Tsuruoka, Yamagata, Japan., Arakawa K; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan., Takebayashi T; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.; Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Source: GeroScience [Geroscience] 2026 Jul 18. Date of Electronic Publication: 2026 Jul 18.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Toki+R%22">Toki R</searchLink>; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. rtoki@keio.jp.<br /><searchLink fieldCode="AU" term="%22Iba+C%22">Iba C</searchLink>; Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Omoto+Y%22">Omoto Y</searchLink>; Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Matsumoto+M%22">Matsumoto M</searchLink>; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.<br /><searchLink fieldCode="AU" term="%22Iida+M%22">Iida M</searchLink>; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.<br /><searchLink fieldCode="AU" term="%22Edagawa+S%22">Edagawa S</searchLink>; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.<br /><searchLink fieldCode="AU" term="%22Harada+S%22">Harada S</searchLink>; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.<br /><searchLink fieldCode="AU" term="%22Hirata+A%22">Hirata A</searchLink>; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.<br /><searchLink fieldCode="AU" term="%22Miyagawa+N%22">Miyagawa N</searchLink>; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.<br /><searchLink fieldCode="AU" term="%22Miyake+A%22">Miyake A</searchLink>; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.<br /><searchLink fieldCode="AU" term="%22Hirayama+A%22">Hirayama A</searchLink>; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan.<br /><searchLink fieldCode="AU" term="%22Sugimoto+M%22">Sugimoto M</searchLink>; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+A%22">Sato A</searchLink>; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan.<br /><searchLink fieldCode="AU" term="%22Amano+K%22">Amano K</searchLink>; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan.<br /><searchLink fieldCode="AU" term="%22Soga+T%22">Soga T</searchLink>; Human Biology-Microbiome-Quantum Research Center, Keio University, Tsuruoka, Yamagata, Japan.<br /><searchLink fieldCode="AU" term="%22Arakawa+K%22">Arakawa K</searchLink>; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan.<br /><searchLink fieldCode="AU" term="%22Takebayashi+T%22">Takebayashi T</searchLink>; Department of Preventive Medicine and Public Health, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.; Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
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              Text: 2026 Jul 18
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