OPTIM: a randomized phase II trial of nivolumab followed by nivolumab-ipilimumab or docetaxel at progression in recurrent/metastatic squamous cell carcinoma of the head and neck (OPTIM; AIO-KHT-0117).

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Title: OPTIM: a randomized phase II trial of nivolumab followed by nivolumab-ipilimumab or docetaxel at progression in recurrent/metastatic squamous cell carcinoma of the head and neck (OPTIM; AIO-KHT-0117).
Authors: Grünwald V; Carolus Institute of Urologic Oncology, University Hospital Essen, Essen, Germany. viktor.gruenwald@uk-essen.de., Alt J; III. Med. Klinik u. Poliklinik, University Hospital Mainz, Mainz, Germany., Tometten M; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany., Hänel M; Internal Medicine, Hospital Chemnitz, Chemnitz, Germany., Ivanyi P; Dept. Hematology, Hemostasis, Oncology & Stem Cell Transpl., Medical School Hanover, Hanover, Germany., Schuch G; Hematology and Oncology Practice Altona, Hamburg, Germany., Klinghammer K; Dept. Medical Oncology, Charite, Berlin, Germany., Gutsche K; Ambulatory Center for Hematology and Oncology, Cottbus, Germany., Hasenkamp J; Clinic for Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany., Hapke G; Hematology and Oncology, Marien Hospital, Hamburg, Germany., Mänz M; Corbin, Berlin, Germany., Mogler C; Institute of Pathology, Techincal University Munich, Munich, Germany., Hahn D; Hematology and Oncology Department, Hospital Stuttgart, Stuttgart, Germany.
Source: British journal of cancer [Br J Cancer] 2026 Jul 18. Date of Electronic Publication: 2026 Jul 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1532-1827
DOI:10.1038/s41416-026-03558-z