View in EDS

OPTIM: a randomized phase II trial of nivolumab followed by nivolumab-ipilimumab or docetaxel at progression in recurrent/metastatic squamous cell carcinoma of the head and neck (OPTIM; AIO-KHT-0117).

Saved in:
Bibliographic Details
Title: OPTIM: a randomized phase II trial of nivolumab followed by nivolumab-ipilimumab or docetaxel at progression in recurrent/metastatic squamous cell carcinoma of the head and neck (OPTIM; AIO-KHT-0117).
Authors: Grünwald V; Carolus Institute of Urologic Oncology, University Hospital Essen, Essen, Germany. viktor.gruenwald@uk-essen.de., Alt J; III. Med. Klinik u. Poliklinik, University Hospital Mainz, Mainz, Germany., Tometten M; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany., Hänel M; Internal Medicine, Hospital Chemnitz, Chemnitz, Germany., Ivanyi P; Dept. Hematology, Hemostasis, Oncology & Stem Cell Transpl., Medical School Hanover, Hanover, Germany., Schuch G; Hematology and Oncology Practice Altona, Hamburg, Germany., Klinghammer K; Dept. Medical Oncology, Charite, Berlin, Germany., Gutsche K; Ambulatory Center for Hematology and Oncology, Cottbus, Germany., Hasenkamp J; Clinic for Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany., Hapke G; Hematology and Oncology, Marien Hospital, Hamburg, Germany., Mänz M; Corbin, Berlin, Germany., Mogler C; Institute of Pathology, Techincal University Munich, Munich, Germany., Hahn D; Hematology and Oncology Department, Hospital Stuttgart, Stuttgart, Germany.
Source: British journal of cancer [Br J Cancer] 2026 Jul 18. Date of Electronic Publication: 2026 Jul 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42471483
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: OPTIM: a randomized phase II trial of nivolumab followed by nivolumab-ipilimumab or docetaxel at progression in recurrent/metastatic squamous cell carcinoma of the head and neck (OPTIM; AIO-KHT-0117).
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Grünwald+V%22">Grünwald V</searchLink>; Carolus Institute of Urologic Oncology, University Hospital Essen, Essen, Germany. viktor.gruenwald@uk-essen.de.<br /><searchLink fieldCode="AU" term="%22Alt+J%22">Alt J</searchLink>; III. Med. Klinik u. Poliklinik, University Hospital Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Tometten+M%22">Tometten M</searchLink>; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Hänel+M%22">Hänel M</searchLink>; Internal Medicine, Hospital Chemnitz, Chemnitz, Germany.<br /><searchLink fieldCode="AU" term="%22Ivanyi+P%22">Ivanyi P</searchLink>; Dept. Hematology, Hemostasis, Oncology & Stem Cell Transpl., Medical School Hanover, Hanover, Germany.<br /><searchLink fieldCode="AU" term="%22Schuch+G%22">Schuch G</searchLink>; Hematology and Oncology Practice Altona, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Klinghammer+K%22">Klinghammer K</searchLink>; Dept. Medical Oncology, Charite, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Gutsche+K%22">Gutsche K</searchLink>; Ambulatory Center for Hematology and Oncology, Cottbus, Germany.<br /><searchLink fieldCode="AU" term="%22Hasenkamp+J%22">Hasenkamp J</searchLink>; Clinic for Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Hapke+G%22">Hapke G</searchLink>; Hematology and Oncology, Marien Hospital, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mänz+M%22">Mänz M</searchLink>; Corbin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mogler+C%22">Mogler C</searchLink>; Institute of Pathology, Techincal University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hahn+D%22">Hahn D</searchLink>; Hematology and Oncology Department, Hospital Stuttgart, Stuttgart, Germany.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220370635%22">British journal of cancer</searchLink> [Br J Cancer] 2026 Jul 18. <i>Date of Electronic Publication: </i>2026 Jul 18.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+on+behalf+of+Cancer+Research+UK%22">Nature Publishing Group on behalf of Cancer Research UK </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0370635 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-1827 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200070920%22">00070920 </searchLink><i>NLM ISO Abbreviation: </i>Br J Cancer <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42471483
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41416-026-03558-z
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: OPTIM: a randomized phase II trial of nivolumab followed by nivolumab-ipilimumab or docetaxel at progression in recurrent/metastatic squamous cell carcinoma of the head and neck (OPTIM; AIO-KHT-0117).
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Grünwald V
      – PersonEntity:
          Name:
            NameFull: Alt J
      – PersonEntity:
          Name:
            NameFull: Tometten M
      – PersonEntity:
          Name:
            NameFull: Hänel M
      – PersonEntity:
          Name:
            NameFull: Ivanyi P
      – PersonEntity:
          Name:
            NameFull: Schuch G
      – PersonEntity:
          Name:
            NameFull: Klinghammer K
      – PersonEntity:
          Name:
            NameFull: Gutsche K
      – PersonEntity:
          Name:
            NameFull: Hasenkamp J
      – PersonEntity:
          Name:
            NameFull: Hapke G
      – PersonEntity:
          Name:
            NameFull: Mänz M
      – PersonEntity:
          Name:
            NameFull: Mogler C
      – PersonEntity:
          Name:
            NameFull: Hahn D
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 18
              M: 07
              Text: 2026 Jul 18
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1532-1827
          Titles:
            – TitleFull: British journal of cancer
              Type: main
ResultId 1