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Generative AI-Assisted Discovery of HPK1 Inhibitors.

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Bibliographic Details
Title: Generative AI-Assisted Discovery of HPK1 Inhibitors.
Authors: Giblin KA; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Song K; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Chen H; Discovery Sciences, R&D, AstraZeneca, Pepparedsleden 1, SE-431 83Mölndal, Sweden., Chen W; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Dong Z; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Escobar RA; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Grebe TP; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Grimster NP; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Hird AW; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Hughes SJ; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Kettle JG; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Li C; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Ma H; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Pflug A; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Richter M; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Schimpl M; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Tang H; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Wang P; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Wrigley G; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Wu Y; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Yu H; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Ziegler RE; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Shields JD; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Aug 13; Vol. 69 (15), pp. 18723-18738.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.6c01048