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Generative AI-Assisted Discovery of HPK1 Inhibitors.

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Title: Generative AI-Assisted Discovery of HPK1 Inhibitors.
Authors: Giblin KA; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Song K; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Chen H; Discovery Sciences, R&D, AstraZeneca, Pepparedsleden 1, SE-431 83Mölndal, Sweden., Chen W; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Dong Z; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Escobar RA; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Grebe TP; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Grimster NP; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Hird AW; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Hughes SJ; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Kettle JG; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Li C; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Ma H; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Pflug A; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Richter M; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Schimpl M; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Tang H; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Wang P; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Wrigley G; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Wu Y; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Yu H; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Ziegler RE; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Shields JD; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Aug 13; Vol. 69 (15), pp. 18723-18738.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Generative AI-Assisted Discovery of HPK1 Inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Giblin+KA%22">Giblin KA</searchLink>; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Song+K%22">Song K</searchLink>; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Discovery Sciences, R&D, AstraZeneca, Pepparedsleden 1, SE-431 83Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Dong+Z%22">Dong Z</searchLink>; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Escobar+RA%22">Escobar RA</searchLink>; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States.<br /><searchLink fieldCode="AU" term="%22Grebe+TP%22">Grebe TP</searchLink>; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States.<br /><searchLink fieldCode="AU" term="%22Grimster+NP%22">Grimster NP</searchLink>; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States.<br /><searchLink fieldCode="AU" term="%22Hird+AW%22">Hird AW</searchLink>; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States.<br /><searchLink fieldCode="AU" term="%22Hughes+SJ%22">Hughes SJ</searchLink>; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Kettle+JG%22">Kettle JG</searchLink>; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Ma+H%22">Ma H</searchLink>; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Pflug+A%22">Pflug A</searchLink>; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Richter+M%22">Richter M</searchLink>; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Schimpl+M%22">Schimpl M</searchLink>; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Tang+H%22">Tang H</searchLink>; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wrigley+G%22">Wrigley G</searchLink>; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China.<br /><searchLink fieldCode="AU" term="%22Ziegler+RE%22">Ziegler RE</searchLink>; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States.<br /><searchLink fieldCode="AU" term="%22Shields+JD%22">Shields JD</searchLink>; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.6c01048
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              Text: 2026 Aug 13
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