Generative AI-Assisted Discovery of HPK1 Inhibitors.
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| Title: | Generative AI-Assisted Discovery of HPK1 Inhibitors. |
|---|---|
| Authors: | Giblin KA; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Song K; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Chen H; Discovery Sciences, R&D, AstraZeneca, Pepparedsleden 1, SE-431 83Mölndal, Sweden., Chen W; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Dong Z; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Escobar RA; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Grebe TP; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Grimster NP; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Hird AW; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Hughes SJ; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Kettle JG; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Li C; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Ma H; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Pflug A; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Richter M; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Schimpl M; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Tang H; Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Wang P; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Wrigley G; Oncology R&D, AstraZeneca, 1 Francis Crick Avenue, CambridgeCB2 0AA, U.K., Wu Y; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Yu H; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing100176, P. R. China., Ziegler RE; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States., Shields JD; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts02451, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2026 Aug 13; Vol. 69 (15), pp. 18723-18738. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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