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Equilibrative nucleoside transporter 1 deficiency protects against diet-induced MASLD and is stage-associated in human liver disease.

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Title: Equilibrative nucleoside transporter 1 deficiency protects against diet-induced MASLD and is stage-associated in human liver disease.
Authors: Mata-Ventosa A; Molecular Pharmacology and Experimental Therapeutics (MPET), Department of Biochemistry and Molecular Biology, University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Institute of Biomedicine (IBUB), University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain., Calvo E; DIAMET Research Group, University Hospital of Tarragona Joan XXIII, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain., Marsal-Beltran A; DIAMET Research Group, University Hospital of Tarragona Joan XXIII, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; Rovira i Virgili University, Tarragona, Spain., Medina-Pulido L; Molecular Pharmacology and Experimental Therapeutics (MPET), Department of Biochemistry and Molecular Biology, University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Institute of Biomedicine (IBUB), University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain., Lozano JJ; CIBER de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain., Ormazábal A; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Clinical Biochemistry Department, Hospital Sant Joan de Déu and CIBERER, Barcelona, Spain., Balaguer-Román A; Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain; Department of General and Digestive System Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain., Frutos MD; Department of General and Digestive System Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain., Artuch R; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Clinical Biochemistry Department, Hospital Sant Joan de Déu and CIBERER, Barcelona, Spain., Cámara Y; Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, and Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona, Spain., Martí R; Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, and Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona, Spain., Rodrigues CMP; Research Institute for Medicines (iMed.ULisboa) Faculty of Pharmacy, Universidade de Lisboa, 1649-003, Lisbon, Portugal., Castro RE; Research Institute for Medicines (iMed.ULisboa) Faculty of Pharmacy, Universidade de Lisboa, 1649-003, Lisbon, Portugal., Hernández-Alvarez MI; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Institute of Biomedicine (IBUB), University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain., Ramos-Molina B; Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain., Pastor-Anglada M; Molecular Pharmacology and Experimental Therapeutics (MPET), Department of Biochemistry and Molecular Biology, University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Institute of Biomedicine (IBUB), University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain., Fernández-Veledo S; DIAMET Research Group, University Hospital of Tarragona Joan XXIII, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; Rovira i Virgili University, Tarragona, Spain. Electronic address: sonia.fernandez@iispv.cat., Pérez-Torras S; Molecular Pharmacology and Experimental Therapeutics (MPET), Department of Biochemistry and Molecular Biology, University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Institute of Biomedicine (IBUB), University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain. Electronic address: s.perez-torras@ub.edu.
Source: Metabolism: clinical and experimental [Metabolism] 2026 Jul 21, pp. 156710. Date of Electronic Publication: 2026 Jul 21.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Equilibrative nucleoside transporter 1 deficiency protects against diet-induced MASLD and is stage-associated in human liver disease.
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  Data: <searchLink fieldCode="AU" term="%22Mata-Ventosa+A%22">Mata-Ventosa A</searchLink>; Molecular Pharmacology and Experimental Therapeutics (MPET), Department of Biochemistry and Molecular Biology, University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Institute of Biomedicine (IBUB), University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Calvo+E%22">Calvo E</searchLink>; DIAMET Research Group, University Hospital of Tarragona Joan XXIII, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Marsal-Beltran+A%22">Marsal-Beltran A</searchLink>; DIAMET Research Group, University Hospital of Tarragona Joan XXIII, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; Rovira i Virgili University, Tarragona, Spain.<br /><searchLink fieldCode="AU" term="%22Medina-Pulido+L%22">Medina-Pulido L</searchLink>; Molecular Pharmacology and Experimental Therapeutics (MPET), Department of Biochemistry and Molecular Biology, University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Institute of Biomedicine (IBUB), University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Lozano+JJ%22">Lozano JJ</searchLink>; CIBER de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ormazábal+A%22">Ormazábal A</searchLink>; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Clinical Biochemistry Department, Hospital Sant Joan de Déu and CIBERER, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Balaguer-Román+A%22">Balaguer-Román A</searchLink>; Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain; Department of General and Digestive System Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Frutos+MD%22">Frutos MD</searchLink>; Department of General and Digestive System Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Artuch+R%22">Artuch R</searchLink>; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Clinical Biochemistry Department, Hospital Sant Joan de Déu and CIBERER, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Cámara+Y%22">Cámara Y</searchLink>; Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, and Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Martí+R%22">Martí R</searchLink>; Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, and Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodrigues+CMP%22">Rodrigues CMP</searchLink>; Research Institute for Medicines (iMed.ULisboa) Faculty of Pharmacy, Universidade de Lisboa, 1649-003, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Castro+RE%22">Castro RE</searchLink>; Research Institute for Medicines (iMed.ULisboa) Faculty of Pharmacy, Universidade de Lisboa, 1649-003, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Hernández-Alvarez+MI%22">Hernández-Alvarez MI</searchLink>; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Institute of Biomedicine (IBUB), University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ramos-Molina+B%22">Ramos-Molina B</searchLink>; Obesity, Diabetes and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Pastor-Anglada+M%22">Pastor-Anglada M</searchLink>; Molecular Pharmacology and Experimental Therapeutics (MPET), Department of Biochemistry and Molecular Biology, University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Institute of Biomedicine (IBUB), University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Veledo+S%22">Fernández-Veledo S</searchLink>; DIAMET Research Group, University Hospital of Tarragona Joan XXIII, Pere Virgili Health Research Institute (IISPV), Tarragona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; Rovira i Virgili University, Tarragona, Spain. Electronic address: sonia.fernandez@iispv.cat.<br /><searchLink fieldCode="AU" term="%22Pérez-Torras+S%22">Pérez-Torras S</searchLink>; Molecular Pharmacology and Experimental Therapeutics (MPET), Department of Biochemistry and Molecular Biology, University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IRSJD), Santa Rosa 39-57, 08950, Esplugues de Llobregat, Spain; Institute of Biomedicine (IBUB), University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain. Electronic address: s.perez-torras@ub.edu.
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