Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy.
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| Title: | Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. |
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| Authors: | Noureddine M; Department of Cardiovascular Sciences, University of Birmingham, Birmingham, UK. m.noureddine@bham.ac.uk., Mikolajek H; Diamond Light Source Ltd, Didcot, UK., Cowieson N; Diamond Light Source Ltd, Didcot, UK., Pinotsis N; Institute of Structural and Molecular Biology, Birkbeck College, London, UK., Robinson P; Division of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence Oxford, University of Oxford, Oxford, UK., Slater A; Department of Cardiovascular Sciences, University of Birmingham, Birmingham, UK., Redwood C; Division of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence Oxford, University of Oxford, Oxford, UK., Loughna S; School of Life Sciences, University of Nottingham, Nottingham, UK., Denning C; Biodiscovery Institute, University of Nottingham, Nottingham, UK., Mohammed F; Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. f.mohammed@bham.ac.uk., Gehmlich K; Department of Cardiovascular Sciences, University of Birmingham, Birmingham, UK. k.gehmlich@bham.ac.uk.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence Oxford, University of Oxford, Oxford, UK. k.gehmlich@bham.ac.uk. |
| Source: | Nature communications [Nat Commun] 2026 Jul 21; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-75392-z |
