A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair.

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Title: A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair.
Authors: Salm L; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, Visceral Surgery and Medicine, University of Bern, Bern, Switzerland.; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada., Lopez MA; Department of Biomedical and Molecular Science, Queen's University, Kingston, Canada., Jenkins E; Kennedy Institute of Rheumatology, University of Oxford , Oxford, UK., Shim R; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada., Tejada O; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada., Abou Mehrem B; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada., Huang S; Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada.; Department of Microbiology, Immunology, and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada., Etemadi Nezhad P; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada., Derakhshani A; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada.; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary , Calgary, Canada., Lee WY; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Biomedical and Molecular Science, Queen's University, Kingston, Canada., Nusse Y; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada., Mewburn JB; Department of Biomedical and Molecular Science, Queen's University, Kingston, Canada., Noskovicova N; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada., Bayer J; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, Visceral Surgery and Medicine, University of Bern, Bern, Switzerland., Rashid MU; Department of Biomedical and Molecular Science, Queen's University, Kingston, Canada., Li X; Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA., Baltaci Z; Program in Molecular Medicine, Hospital for Sick Children , Toronto, Canada.; Program in Cell & Systems Biology, Hospital for Sick Children , Toronto, Canada.; Department of Biochemistry, University of Toronto, Toronto, Canada., Young D; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada.; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary , Calgary, Canada., Carneiro MB; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada., Fritzsche M; Kennedy Institute of Rheumatology, University of Oxford , Oxford, UK., Jakubzick CV; Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA., Peters NC; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada., Deniset JF; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Cardiac Sciences, University of Calgary, Calgary, Canada.; Libin Cardiovascular Institute, University of Calgary , Calgary, Canada., Zindel J; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, Visceral Surgery and Medicine, University of Bern, Bern, Switzerland.; Department of Biology, Institute of Molecular Health Sciences, Federal Institute of Technology (ETH) Zürich, Switzerland., Dufour A; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada.; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary , Calgary, Canada., Yipp BG; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Canada., Ditlev JA; Program in Molecular Medicine, Hospital for Sick Children , Toronto, Canada.; Program in Cell & Systems Biology, Hospital for Sick Children , Toronto, Canada.; Department of Biochemistry, University of Toronto, Toronto, Canada., Dustin ML; Kennedy Institute of Rheumatology, University of Oxford , Oxford, UK., Canton J; Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada.; Department of Microbiology, Immunology, and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada., Kubes P; Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada.; Department of Biomedical and Molecular Science, Queen's University, Kingston, Canada.
Source: The Journal of experimental medicine [J Exp Med] 2026 Aug 03; Vol. 223 (8). Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1540-9538
DOI:10.1084/jem.20260410