Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity.
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| Title: | Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity. |
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| Authors: | Panel N; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Vo DD; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. duc.duy.vo@kemi.uu.se.; Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden. duc.duy.vo@kemi.uu.se., Hübner H; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Deluigi M; Department of Biochemistry, University of Zurich, Zürich, Switzerland., Pach S; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Bélair F; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institute de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada., Weikert D; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; FAUNeW - Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, Erlangen, Germany., Klenk C; Department of Biochemistry, University of Zurich, Zürich, Switzerland.; Rudolf Buchheim Institute of Pharmacology, Justus Liebig University, Giessen, Germany., Hilge M; Department of Biochemistry, University of Zurich, Zürich, Switzerland., Shiva N; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Brochu I; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institute de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada., Longpré JM; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institute de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada., Bällgren F; Department of Pharmacy, SciLifeLab Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Saleh A; Department of Pharmacy, SciLifeLab Drug Discovery and Development, Uppsala University, Uppsala, Sweden., Hu H; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Kapla J; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Kampen S; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Cabeza de Vaca I; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden., Kihlberg J; Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden., Wettschureck N; Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Centre for Molecular Medicine, Medical Faculty, Goethe University, Frankfurt am Main, Germany., Sarret P; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institute de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada. philippe.sarret@usherbrooke.ca., Plückthun A; Department of Biochemistry, University of Zurich, Zürich, Switzerland. plueckthun@bioc.uzh.ch., Gmeiner P; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. peter.gmeiner@fau.de.; FAUNeW - Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, Erlangen, Germany. peter.gmeiner@fau.de., Carlsson J; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. jens.carlsson@icm.uu.se. |
| Source: | Nature communications [Nat Commun] 2026 Jul 22; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 22. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-74990-1 |
