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Targeting JOSD2 degrades β-catenin to suppress colorectal cancer metastasis by disrupting RAS/ERK/β-catenin axis.

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Title: Targeting JOSD2 degrades β-catenin to suppress colorectal cancer metastasis by disrupting RAS/ERK/β-catenin axis.
Authors: Liu Y; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Yang SY; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Zhang WH; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Liang YT; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Fu JW; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Dai JY; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Wu RL; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Zheng CR; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Wang HT; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Li YH; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Guo RQ; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Zeng CM; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Xu XY; Center for Drug Safety Evaluation and Research of Zhejiang University, Hangzhou, 310058, China., Song ZB; Zhejiang Cancer Hospital, Hangzhou, 310022, China., Xu CW; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, 310022, China., Cao J; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., He QJ; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Zhu H; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China., Yuan T; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China. 11919006@zju.edu.cn., Yang B; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China. yang924@zju.edu.cn.; School of Medicine, Hangzhou City University, Hangzhou, 310000, China. yang924@zju.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jul 22. Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting JOSD2 degrades β-catenin to suppress colorectal cancer metastasis by disrupting RAS/ERK/β-catenin axis.
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  Data: <searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Yang+SY%22">Yang SY</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Zhang+WH%22">Zhang WH</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Liang+YT%22">Liang YT</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Fu+JW%22">Fu JW</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Dai+JY%22">Dai JY</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Wu+RL%22">Wu RL</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Zheng+CR%22">Zheng CR</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Wang+HT%22">Wang HT</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Li+YH%22">Li YH</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Guo+RQ%22">Guo RQ</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Zeng+CM%22">Zeng CM</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Xu+XY%22">Xu XY</searchLink>; Center for Drug Safety Evaluation and Research of Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Song+ZB%22">Song ZB</searchLink>; Zhejiang Cancer Hospital, Hangzhou, 310022, China.<br /><searchLink fieldCode="AU" term="%22Xu+CW%22">Xu CW</searchLink>; Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, 310022, China.<br /><searchLink fieldCode="AU" term="%22Cao+J%22">Cao J</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22He+QJ%22">He QJ</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Zhu+H%22">Zhu H</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Yuan+T%22">Yuan T</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China. 11919006@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; College of Pharmaceutical Sciences, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Zhejiang University, Hangzhou, 310058, China. yang924@zju.edu.cn.; School of Medicine, Hangzhou City University, Hangzhou, 310000, China. yang924@zju.edu.cn.
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              Text: 2026 Jul 22
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