Single-cell multiomics and chromatin structure reveal gene-regulatory dynamics in heart failure.
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| Title: | Single-cell multiomics and chromatin structure reveal gene-regulatory dynamics in heart failure. |
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| Authors: | Xie Y; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; New York Genome Center, New York, NY, USA., Tucciarone L; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Farah EN; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA., Chang L; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; New York Genome Center, New York, NY, USA., Yang Q; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Shankar TS; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA., Elison W; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA., Tran S; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA., Djulamsah J; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Lie A; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Loe T; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Holman AR; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA., Corban S; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Buchanan J; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Mamde S; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Bioengineering Graduate Program, University of California San Diego, La Jolla, CA, USA., Zhou H; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA., Elgamal RM; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA., Tseliou E; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.; Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, USA., Huang V; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.; Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, USA., Wang Z; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA., Chiu JH; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA., Melton R; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA., Griffin E; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Zhang Q; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA., Lucero J; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Navankasattusas S; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA., Li D; Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Seng C; Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Destici E; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA., Selzman CH; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.; Division of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT, USA., D'Antonio-Chronowska A; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Wang T; Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Wang A; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Drakos SG; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.; Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, USA., Gaulton KJ; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA., Ren B; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; New York Genome Center, New York, NY, USA.; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA.; Institute for Genomic Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Department of Systems Biology, Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA., Chi NC; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA.; Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA. |
| Source: | Science (New York, N.Y.) [Science] 2026 Jul 23; Vol. 393 (6809), pp. eady6893. Date of Electronic Publication: 2026 Jul 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.ady6893 |
