View in EDS HTML Full Text PDF Full Text

Single-cell multiomics and chromatin structure reveal gene-regulatory dynamics in heart failure.

Saved in:
Bibliographic Details
Title: Single-cell multiomics and chromatin structure reveal gene-regulatory dynamics in heart failure.
Authors: Xie Y; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; New York Genome Center, New York, NY, USA., Tucciarone L; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Farah EN; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA., Chang L; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; New York Genome Center, New York, NY, USA., Yang Q; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Shankar TS; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA., Elison W; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA., Tran S; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA., Djulamsah J; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Lie A; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Loe T; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Holman AR; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA., Corban S; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Buchanan J; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Mamde S; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Bioengineering Graduate Program, University of California San Diego, La Jolla, CA, USA., Zhou H; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA., Elgamal RM; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA., Tseliou E; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.; Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, USA., Huang V; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.; Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, USA., Wang Z; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA., Chiu JH; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA., Melton R; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA., Griffin E; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Zhang Q; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA., Lucero J; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Navankasattusas S; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA., Li D; Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Seng C; Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Destici E; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA., Selzman CH; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.; Division of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT, USA., D'Antonio-Chronowska A; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Wang T; Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Wang A; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Drakos SG; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.; Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, USA., Gaulton KJ; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA., Ren B; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; New York Genome Center, New York, NY, USA.; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA.; Institute for Genomic Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Department of Systems Biology, Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA., Chi NC; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA.; Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.
Source: Science (New York, N.Y.) [Science] 2026 Jul 23; Vol. 393 (6809), pp. eady6893. Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42490484
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Single-cell multiomics and chromatin structure reveal gene-regulatory dynamics in heart failure.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Xie+Y%22">Xie Y</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; New York Genome Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tucciarone+L%22">Tucciarone L</searchLink>; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Farah+EN%22">Farah EN</searchLink>; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+L%22">Chang L</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; New York Genome Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Q%22">Yang Q</searchLink>; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shankar+TS%22">Shankar TS</searchLink>; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Elison+W%22">Elison W</searchLink>; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tran+S%22">Tran S</searchLink>; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Djulamsah+J%22">Djulamsah J</searchLink>; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lie+A%22">Lie A</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Loe+T%22">Loe T</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Holman+AR%22">Holman AR</searchLink>; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Corban+S%22">Corban S</searchLink>; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Buchanan+J%22">Buchanan J</searchLink>; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mamde+S%22">Mamde S</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Bioengineering Graduate Program, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+H%22">Zhou H</searchLink>; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Elgamal+RM%22">Elgamal RM</searchLink>; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tseliou+E%22">Tseliou E</searchLink>; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.; Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Huang+V%22">Huang V</searchLink>; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.; Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chiu+JH%22">Chiu JH</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Melton+R%22">Melton R</searchLink>; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Griffin+E%22">Griffin E</searchLink>; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lucero+J%22">Lucero J</searchLink>; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Navankasattusas+S%22">Navankasattusas S</searchLink>; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Seng+C%22">Seng C</searchLink>; Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Destici+E%22">Destici E</searchLink>; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Selzman+CH%22">Selzman CH</searchLink>; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.; Division of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22D'Antonio-Chronowska+A%22">D'Antonio-Chronowska A</searchLink>; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Wang+A%22">Wang A</searchLink>; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Drakos+SG%22">Drakos SG</searchLink>; Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.; Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Gaulton+KJ%22">Gaulton KJ</searchLink>; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ren+B%22">Ren B</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; New York Genome Center, New York, NY, USA.; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA.; Institute for Genomic Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.; Department of Systems Biology, Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chi+NC%22">Chi NC</searchLink>; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, School of Medicine, University of California San Diego, La Jolla, CA, USA.; Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 Jul 23; Vol. 393 (6809), pp. eady6893. <i>Date of Electronic Publication: </i>2026 Jul 23.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0404511 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-9203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200368075%22">00368075 </searchLink><i>NLM ISO Abbreviation: </i>Science <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42490484
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.ady6893
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: eady6893
    Titles:
      – TitleFull: Single-cell multiomics and chromatin structure reveal gene-regulatory dynamics in heart failure.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Xie Y
      – PersonEntity:
          Name:
            NameFull: Tucciarone L
      – PersonEntity:
          Name:
            NameFull: Farah EN
      – PersonEntity:
          Name:
            NameFull: Chang L
      – PersonEntity:
          Name:
            NameFull: Yang Q
      – PersonEntity:
          Name:
            NameFull: Shankar TS
      – PersonEntity:
          Name:
            NameFull: Elison W
      – PersonEntity:
          Name:
            NameFull: Tran S
      – PersonEntity:
          Name:
            NameFull: Djulamsah J
      – PersonEntity:
          Name:
            NameFull: Lie A
      – PersonEntity:
          Name:
            NameFull: Loe T
      – PersonEntity:
          Name:
            NameFull: Holman AR
      – PersonEntity:
          Name:
            NameFull: Corban S
      – PersonEntity:
          Name:
            NameFull: Buchanan J
      – PersonEntity:
          Name:
            NameFull: Mamde S
      – PersonEntity:
          Name:
            NameFull: Zhou H
      – PersonEntity:
          Name:
            NameFull: Elgamal RM
      – PersonEntity:
          Name:
            NameFull: Tseliou E
      – PersonEntity:
          Name:
            NameFull: Huang V
      – PersonEntity:
          Name:
            NameFull: Wang Z
      – PersonEntity:
          Name:
            NameFull: Chiu JH
      – PersonEntity:
          Name:
            NameFull: Melton R
      – PersonEntity:
          Name:
            NameFull: Griffin E
      – PersonEntity:
          Name:
            NameFull: Zhang Q
      – PersonEntity:
          Name:
            NameFull: Lucero J
      – PersonEntity:
          Name:
            NameFull: Navankasattusas S
      – PersonEntity:
          Name:
            NameFull: Li D
      – PersonEntity:
          Name:
            NameFull: Seng C
      – PersonEntity:
          Name:
            NameFull: Destici E
      – PersonEntity:
          Name:
            NameFull: Selzman CH
      – PersonEntity:
          Name:
            NameFull: D'Antonio-Chronowska A
      – PersonEntity:
          Name:
            NameFull: Wang T
      – PersonEntity:
          Name:
            NameFull: Wang A
      – PersonEntity:
          Name:
            NameFull: Drakos SG
      – PersonEntity:
          Name:
            NameFull: Gaulton KJ
      – PersonEntity:
          Name:
            NameFull: Ren B
      – PersonEntity:
          Name:
            NameFull: Chi NC
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 23
              M: 07
              Text: 2026 Jul 23
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1095-9203
          Numbering:
            – Type: volume
              Value: 393
            – Type: issue
              Value: 6809
          Titles:
            – TitleFull: Science (New York, N.Y.)
              Type: main
ResultId 1