Heart rate fragmentation as a marker of autonomic function in healthy young individuals: insights from graded head-up tilt test and controlled breathing.

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Title: Heart rate fragmentation as a marker of autonomic function in healthy young individuals: insights from graded head-up tilt test and controlled breathing.
Authors: da Silva TM; Department of Physiology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil.; Department of Clinical Sciences and Community Health, Department of Excellence 2023-2027, Policlinico, Milan, Italy., Carandina A; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Scatà C; Department of Clinical Sciences and Community Health, Department of Excellence 2023-2027, Policlinico, Milan, Italy., Salafia G; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Magna F; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Giobbi LS; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Rodrigues GD; Department of Clinical Sciences and Community Health, Department of Excellence 2023-2027, Policlinico, Milan, Italy.; Department of Physiology and Pharmacology, Federal Fluminense University, Niterói, RJ, Brazil., Tobaldini E; Department of Clinical Sciences and Community Health, Department of Excellence 2023-2027, Policlinico, Milan, Italy.; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Silva LEV; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Salgado HC; Department of Physiology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil., Fazan R Jr; Department of Physiology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, Brazil., Montano N; Department of Clinical Sciences and Community Health, Department of Excellence 2023-2027, Policlinico, Milan, Italy.; Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Source: Frontiers in physiology [Front Physiol] 2026 Jul 03; Vol. 17, pp. 1880925. Date of Electronic Publication: 2026 Jul 03 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-042X
DOI:10.3389/fphys.2026.1880925