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Modular delivery of co-stimulatory signals through a PD-1-based immunoswitch receptor improves the functionality of Hepatitis B Virus-specific engineered T cells.

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Title: Modular delivery of co-stimulatory signals through a PD-1-based immunoswitch receptor improves the functionality of Hepatitis B Virus-specific engineered T cells.
Authors: Olguín-Contreras LF; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany., Heep J; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany., Schiller L; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany., Loffredo-Verde E; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany., Festag MM; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany., Metzger K; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany., Färber S; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany., Gültan M; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany., Tulessin M; Institute of Pathology, Technical University of Munich, School of Medicine and Health, Munich, Germany., Wilde S; SCG Cell Therapy GmbH, Munich, Germany., Wisskirchen K; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany.; SCG Cell Therapy GmbH, Munich, Germany., Noessner E; Immunanalytics-Tissue Control of Immunocytes, Helmholtz Center Munich, Munich, Germany., Protzer U; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany.; Institute of Virology, Helmholtz Center Munich, Munich, Germany.
Source: Frontiers in immunology [Front Immunol] 2026 Jul 03; Vol. 17, pp. 1821414. Date of Electronic Publication: 2026 Jul 03 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Modular delivery of co-stimulatory signals through a PD-1-based immunoswitch receptor improves the functionality of Hepatitis B Virus-specific engineered T cells.
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  Data: <searchLink fieldCode="AU" term="%22Olguín-Contreras+LF%22">Olguín-Contreras LF</searchLink>; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Heep+J%22">Heep J</searchLink>; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schiller+L%22">Schiller L</searchLink>; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Loffredo-Verde+E%22">Loffredo-Verde E</searchLink>; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Festag+MM%22">Festag MM</searchLink>; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Metzger+K%22">Metzger K</searchLink>; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Färber+S%22">Färber S</searchLink>; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gültan+M%22">Gültan M</searchLink>; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Tulessin+M%22">Tulessin M</searchLink>; Institute of Pathology, Technical University of Munich, School of Medicine and Health, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wilde+S%22">Wilde S</searchLink>; SCG Cell Therapy GmbH, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wisskirchen+K%22">Wisskirchen K</searchLink>; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany.; SCG Cell Therapy GmbH, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Noessner+E%22">Noessner E</searchLink>; Immunanalytics-Tissue Control of Immunocytes, Helmholtz Center Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Protzer+U%22">Protzer U</searchLink>; Institute of Virology, Technical University of Munich, School of Medicine and Health, Munich, Germany.; Institute of Virology, Helmholtz Center Munich, Munich, Germany.
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