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cPRC1.2 and CTCF-mediated transition from poised to active chromatin loops at bivalent genes.

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Title: cPRC1.2 and CTCF-mediated transition from poised to active chromatin loops at bivalent genes.
Authors: Hanafiah A; Department of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA.; Penn State Hershey Cancer Institute, Hershey, PA, 17033, USA., Geng Z; Department of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA.; Penn State Hershey Cancer Institute, Hershey, PA, 17033, USA., Liu T; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Center for Cancer Genomics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Tai YT; Department of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA.; Penn State Hershey Cancer Institute, Hershey, PA, 17033, USA., Cai W; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Wang Q; Department of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA.; Penn State Hershey Cancer Institute, Hershey, PA, 17033, USA., Christensen N; Department of Pathology and Laboratory Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA., Liu Y; Center for Cancer Genomics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Yue F; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. Yue@Northwestern.edu.; Center for Cancer Genomics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. Yue@Northwestern.edu., Gao Z; Department of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA. gaozhonghua@suat-sz.edu.cn.; Penn State Hershey Cancer Institute, Hershey, PA, 17033, USA. gaozhonghua@suat-sz.edu.cn.; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen, Guangdong, China. gaozhonghua@suat-sz.edu.cn.; Institute of Synthetic Biomedicine, Shenzhen University of Advanced Technology, Shenzhen, Guangdong, China. gaozhonghua@suat-sz.edu.cn.
Source: EMBO reports [EMBO Rep] 2026 Jul 23. Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hanafiah+A%22">Hanafiah A</searchLink>; Department of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA.; Penn State Hershey Cancer Institute, Hershey, PA, 17033, USA.<br /><searchLink fieldCode="AU" term="%22Geng+Z%22">Geng Z</searchLink>; Department of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA.; Penn State Hershey Cancer Institute, Hershey, PA, 17033, USA.<br /><searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Center for Cancer Genomics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Tai+YT%22">Tai YT</searchLink>; Department of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA.; Penn State Hershey Cancer Institute, Hershey, PA, 17033, USA.<br /><searchLink fieldCode="AU" term="%22Cai+W%22">Cai W</searchLink>; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA.; Penn State Hershey Cancer Institute, Hershey, PA, 17033, USA.<br /><searchLink fieldCode="AU" term="%22Christensen+N%22">Christensen N</searchLink>; Department of Pathology and Laboratory Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Center for Cancer Genomics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Yue+F%22">Yue F</searchLink>; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. Yue@Northwestern.edu.; Center for Cancer Genomics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA. Yue@Northwestern.edu.<br /><searchLink fieldCode="AU" term="%22Gao+Z%22">Gao Z</searchLink>; Department of Molecular and Precision Medicine, Penn State College of Medicine, Hershey, PA, 17033, USA. gaozhonghua@suat-sz.edu.cn.; Penn State Hershey Cancer Institute, Hershey, PA, 17033, USA. gaozhonghua@suat-sz.edu.cn.; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen, Guangdong, China. gaozhonghua@suat-sz.edu.cn.; Institute of Synthetic Biomedicine, Shenzhen University of Advanced Technology, Shenzhen, Guangdong, China. gaozhonghua@suat-sz.edu.cn.
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              Text: 2026 Jul 23
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