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The evolution of tecovirimat resistance in an immunocompromised individual with severe mpox infection.

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Title: The evolution of tecovirimat resistance in an immunocompromised individual with severe mpox infection.
Authors: Bholah S; King's College Hospital, London, UK., Davis C; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, G61 1QH, UK., Smollett K; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, G61 1QH, UK., Orton RJ; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, G61 1QH, UK., Lampejo T; King's College Hospital, London, UK., Mendonca DC; CVR Translational Hub, MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, UK., Upfold NS; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, G61 1QH, UK., Nettlemill A; UK Health Security Agency, Porton Down, UK., Hewitt M; UK Health Security Agency, Porton Down, UK., Hartman H; UK Health Security Agency, Porton Down, UK., Pullan S; UK Health Security Agency, Porton Down, UK., Semple MG; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Liverpool Institute of Child Health and Wellbeing, Alder Hey Children's Hospital, Liverpool, UK., Quinn K; King's College Hospital, London, UK., Filipe ADS; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, G61 1QH, UK., Rampling T; UK Health Security Agency, Porton Down, UK; National Institute for Health and Care Research (NIHR) University College London Hospitals Biomedical Research Centre (BRC), London, United Kingdom., Patel AH; CVR Translational Hub, MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, UK., Ho A; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, G61 1QH, UK. Electronic address: Antonia.Ho@glasgow.ac.uk.
Corporate Authors: ISARIC4C investigators
Source: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2026 Jul 22; Vol. 116 (3), pp. 117562. Date of Electronic Publication: 2026 Jul 22.
Publication Type: Case Reports; Journal Article
Journal Info: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8305899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0070 (Electronic) Linking ISSN: 07328893 NLM ISO Abbreviation: Diagn Microbiol Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The evolution of tecovirimat resistance in an immunocompromised individual with severe mpox infection.
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  Data: <searchLink fieldCode="AU" term="%22Bholah+S%22">Bholah S</searchLink>; King's College Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Davis+C%22">Davis C</searchLink>; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Smollett+K%22">Smollett K</searchLink>; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Orton+RJ%22">Orton RJ</searchLink>; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Lampejo+T%22">Lampejo T</searchLink>; King's College Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Mendonca+DC%22">Mendonca DC</searchLink>; CVR Translational Hub, MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Upfold+NS%22">Upfold NS</searchLink>; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Nettlemill+A%22">Nettlemill A</searchLink>; UK Health Security Agency, Porton Down, UK.<br /><searchLink fieldCode="AU" term="%22Hewitt+M%22">Hewitt M</searchLink>; UK Health Security Agency, Porton Down, UK.<br /><searchLink fieldCode="AU" term="%22Hartman+H%22">Hartman H</searchLink>; UK Health Security Agency, Porton Down, UK.<br /><searchLink fieldCode="AU" term="%22Pullan+S%22">Pullan S</searchLink>; UK Health Security Agency, Porton Down, UK.<br /><searchLink fieldCode="AU" term="%22Semple+MG%22">Semple MG</searchLink>; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; Liverpool Institute of Child Health and Wellbeing, Alder Hey Children's Hospital, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Quinn+K%22">Quinn K</searchLink>; King's College Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Filipe+ADS%22">Filipe ADS</searchLink>; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Rampling+T%22">Rampling T</searchLink>; UK Health Security Agency, Porton Down, UK; National Institute for Health and Care Research (NIHR) University College London Hospitals Biomedical Research Centre (BRC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Patel+AH%22">Patel AH</searchLink>; CVR Translational Hub, MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Ho+A%22">Ho A</searchLink>; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, G61 1QH, UK. Electronic address: Antonia.Ho@glasgow.ac.uk.
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        Text: English
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