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Setmelanotide alleviates diabetes-associated cognitive impairment by interrupting the binding of ICAM-1 and JIP1 in endothelial cells of the blood-brain barrier.

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Title: Setmelanotide alleviates diabetes-associated cognitive impairment by interrupting the binding of ICAM-1 and JIP1 in endothelial cells of the blood-brain barrier.
Authors: Wu SD; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Wang X; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Zhou YM; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Hu B; Jiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Wang KY; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Yan CJ; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Zhu HY; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Li H; Jiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Wang XC; Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China., Wang HP; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, 221004, China., Cheng AF; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macao, SAR, 999078, China., Zhu ZS; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, 221004, China. Electronic address: victorzhu2013@xzhmu.edu.cn., Ying CJ; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, 221004, China; Department of Endocrinology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China.. Electronic address: ycj321651@163.com., Zhou XY; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, 221004, China. Electronic address: zhouxiaoyan0201@xzhmu.edu.cn.
Source: Metabolism: clinical and experimental [Metabolism] 2026 Jul 24, pp. 156712. Date of Electronic Publication: 2026 Jul 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Setmelanotide alleviates diabetes-associated cognitive impairment by interrupting the binding of ICAM-1 and JIP1 in endothelial cells of the blood-brain barrier.
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  Data: <searchLink fieldCode="AU" term="%22Wu+SD%22">Wu SD</searchLink>; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.<br /><searchLink fieldCode="AU" term="%22Zhou+YM%22">Zhou YM</searchLink>; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.<br /><searchLink fieldCode="AU" term="%22Hu+B%22">Hu B</searchLink>; Jiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.<br /><searchLink fieldCode="AU" term="%22Wang+KY%22">Wang KY</searchLink>; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.<br /><searchLink fieldCode="AU" term="%22Yan+CJ%22">Yan CJ</searchLink>; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.<br /><searchLink fieldCode="AU" term="%22Zhu+HY%22">Zhu HY</searchLink>; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Jiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.<br /><searchLink fieldCode="AU" term="%22Wang+XC%22">Wang XC</searchLink>; Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China.<br /><searchLink fieldCode="AU" term="%22Wang+HP%22">Wang HP</searchLink>; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, 221004, China.<br /><searchLink fieldCode="AU" term="%22Cheng+AF%22">Cheng AF</searchLink>; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macao, SAR, 999078, China.<br /><searchLink fieldCode="AU" term="%22Zhu+ZS%22">Zhu ZS</searchLink>; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, 221004, China. Electronic address: victorzhu2013@xzhmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ying+CJ%22">Ying CJ</searchLink>; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, 221004, China; Department of Endocrinology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China.. Electronic address: ycj321651@163.com.<br /><searchLink fieldCode="AU" term="%22Zhou+XY%22">Zhou XY</searchLink>; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, 221004, China. Electronic address: zhouxiaoyan0201@xzhmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%220375267%22">Metabolism: clinical and experimental</searchLink> [Metabolism] 2026 Jul 24, pp. 156712. <i>Date of Electronic Publication: </i>2026 Jul 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%22">Elsevier Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0375267 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-8600 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200260495%22">00260495 </searchLink><i>NLM ISO Abbreviation: </i>Metabolism <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.metabol.2026.156712
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      – Code: eng
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              Text: 2026 Jul 24
              Type: published
              Y: 2026
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