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JN.1-adapted vaccination is associated with readjustment of ancestral memory B cells toward neutralization within the JN.1 antigenic space.

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Title: JN.1-adapted vaccination is associated with readjustment of ancestral memory B cells toward neutralization within the JN.1 antigenic space.
Authors: Stankov MV; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany., Bruhn M; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Hoffmann M; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany., Salam A; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Eichmann A; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany., Nehlmeier I; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany., Manthey LA; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany., Witte T; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany., Pöhlmann S; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany.; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany., Ahrenstorf G; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany., Happle C; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.; Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Dopfer-Jablonka A; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany., Kalinke U; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany., Behrens GMN; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany. Behrens.georg@mh-hannover.de.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. Behrens.georg@mh-hannover.de.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany. Behrens.georg@mh-hannover.de.; Center for Individualized Infection Medicine (CiiM), Hannover, Germany. Behrens.georg@mh-hannover.de.
Source: Nature communications [Nat Commun] 2026 Jul 24; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: JN.1-adapted vaccination is associated with readjustment of ancestral memory B cells toward neutralization within the JN.1 antigenic space.
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  Data: <searchLink fieldCode="AU" term="%22Stankov+MV%22">Stankov MV</searchLink>; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Bruhn+M%22">Bruhn M</searchLink>; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+M%22">Hoffmann M</searchLink>; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Salam+A%22">Salam A</searchLink>; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Eichmann+A%22">Eichmann A</searchLink>; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Nehlmeier+I%22">Nehlmeier I</searchLink>; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Manthey+LA%22">Manthey LA</searchLink>; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Witte+T%22">Witte T</searchLink>; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Pöhlmann+S%22">Pöhlmann S</searchLink>; Infection Biology Unit, German Primate Center - Leibniz Institute for Primate Research, Göttingen, Germany.; Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Ahrenstorf+G%22">Ahrenstorf G</searchLink>; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Happle+C%22">Happle C</searchLink>; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.; Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Dopfer-Jablonka+A%22">Dopfer-Jablonka A</searchLink>; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Kalinke+U%22">Kalinke U</searchLink>; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Behrens+GMN%22">Behrens GMN</searchLink>; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany. Behrens.georg@mh-hannover.de.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. Behrens.georg@mh-hannover.de.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany. Behrens.georg@mh-hannover.de.; Center for Individualized Infection Medicine (CiiM), Hannover, Germany. Behrens.georg@mh-hannover.de.
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