Prioritizing Chemotherapy in Total Neoadjuvant Therapy Improves pCR Rate in Locally Advanced Rectal Cancer in Countries with Limited Radiotherapy Access: A Randomized Controlled Trial.

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Title: Prioritizing Chemotherapy in Total Neoadjuvant Therapy Improves pCR Rate in Locally Advanced Rectal Cancer in Countries with Limited Radiotherapy Access: A Randomized Controlled Trial.
Authors: Taheri Z; Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran., Emadi E; Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran., Esfandiary Rad AM; Student Research Committee, Neyshabur University of Medical Science, Neyshabur, Iran., Welsh JS; Department of Radiation Oncology, Loyola University Chicago Stritch School of Medicine, Edward Hines Jr., VA Hospital, Maywood, IL, USA., Mohebbifar Y; Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran., Jalili Bazel S; Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran., Noferesti A; Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Hamrah Siyani M; Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran., Fazilat-Panah D; Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran., Foroughi F; Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Porouhan P; Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran., PeyroShabany B; Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran., Javadinia SA; Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran. javadinia.alireza@gmail.com., Salek R; Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. SalekR@mums.ac.ir.
Source: Journal of gastrointestinal cancer [J Gastrointest Cancer] 2026 Jul 25; Vol. 57 (1). Date of Electronic Publication: 2026 Jul 25.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101479627 Publication Model: Electronic Cited Medium: Internet ISSN: 1941-6636 (Electronic) NLM ISO Abbreviation: J Gastrointest Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1941-6636
DOI:10.1007/s12029-026-01539-2