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Molecular Networks and Key Regulators Underlying Resilience of the Human Brain to Aging and Dementia.

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Title: Molecular Networks and Key Regulators Underlying Resilience of the Human Brain to Aging and Dementia.
Authors: Guo L; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Grimaldi N; Nash Family Department of Neuroscience, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Wang M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Ho L; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Shackleton B; Department of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Neff R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Wang E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Tu Z; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Gandy S; Department of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, 1399 Park Ave, New York, NY 10029, USA.; James J Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA., Haroutunian V; Nash Family Department of Neuroscience, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, 1399 Park Ave, New York, NY 10029, USA.; James J Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA., Ehrlich ME; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Department of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave, New York, NY 10029, USA., Mobbs C; Nash Family Department of Neuroscience, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Department of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Zhang B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
Source: Biomolecules [Biomolecules] 2026 Jul 06; Vol. 16 (7). Date of Electronic Publication: 2026 Jul 06.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Molecular Networks and Key Regulators Underlying Resilience of the Human Brain to Aging and Dementia.
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  Data: <searchLink fieldCode="AU" term="%22Guo+L%22">Guo L</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Grimaldi+N%22">Grimaldi N</searchLink>; Nash Family Department of Neuroscience, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Ho+L%22">Ho L</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Shackleton+B%22">Shackleton B</searchLink>; Department of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Neff+R%22">Neff R</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Wang+E%22">Wang E</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Tu+Z%22">Tu Z</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Gandy+S%22">Gandy S</searchLink>; Department of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, 1399 Park Ave, New York, NY 10029, USA.; James J Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA.<br /><searchLink fieldCode="AU" term="%22Haroutunian+V%22">Haroutunian V</searchLink>; Nash Family Department of Neuroscience, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, 1399 Park Ave, New York, NY 10029, USA.; James J Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA.<br /><searchLink fieldCode="AU" term="%22Ehrlich+ME%22">Ehrlich ME</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Department of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Mobbs+C%22">Mobbs C</searchLink>; Nash Family Department of Neuroscience, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Department of Neurology, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
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