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Integrated biomarkers of oxidative stress NLRP3 inflammasome and kynurenine pathway reflect disease severity and diagnostic discrimination in depression.

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Title: Integrated biomarkers of oxidative stress NLRP3 inflammasome and kynurenine pathway reflect disease severity and diagnostic discrimination in depression.
Authors: AlRasheed HA; Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., El-Hanafy AA; Medical Biochemistry & Molecular Biology, Faculty of Dentistry, Mutah University, Mut'ah, Jordan., Bahaa MM; Pharmacy Practice Department, Faculty of Pharmacy, Horus University, New Damietta, Egypt. mbahaa@horus.edu.eg.; Pharmacy Practice Department, Faculty of Pharmacy, Mansoura National University, Gamasa, Egypt. mbahaa@horus.edu.eg.; Pharmacy Practice Department, Faculty of Pharmacy, East Port said National University, Port Said, Egypt. mbahaa@horus.edu.eg., Hamza E; Department of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia., Kamel MM; Psychiatry Department, Faculty of Medicine, Tanta University, Tanta, Egypt., El-Hanafy DA; Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Eltantawy N; Clinical Pharmacy Department, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt., Yasser M; Pharmaceutical Technology Department, Faculty of Pharmacy, Port Said University, Port Said, Egypt.; Pharmaceutical Technology Department, Faculty of Pharmacy, East Port Said National University, Port Said, Egypt., Al-Dhelaan RA; Department of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia., Radwan KH; Biochemistry Department, Faculty of Physical Therapy, Horus University- Egypt, New Damietta, Egypt., El-Sayed AA; Clinical Pharmacy Department, Faculty of Pharmacy, Sinai University, Alarish Campus, Sinai, Egypt., Eladaroussy MM; Histology and Cell Biology Department, Faculty of Medicine, Horus University-Egypt, New Damietta, Egypt., Kamaleldein Rizk KA; Histology and Cell Biology Department, Faculty of Medicine, Horus University-Egypt, New Damietta, Egypt., Ebrahim MHE; Histology and Cell Biology Department, Faculty of Medicine, Horus University-Egypt, New Damietta, Egypt., Elshorbagi N; Pharmacology and Toxicology Department, Faculty of Pharmacy, Sinai University, East Kantara Branch, New City, Ismailia, , Egypt.
Source: Scientific reports [Sci Rep] 2026 Jul 28; Vol. 16 (1). Date of Electronic Publication: 2026 Jul 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22AlRasheed+HA%22">AlRasheed HA</searchLink>; Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22El-Hanafy+AA%22">El-Hanafy AA</searchLink>; Medical Biochemistry & Molecular Biology, Faculty of Dentistry, Mutah University, Mut'ah, Jordan.<br /><searchLink fieldCode="AU" term="%22Bahaa+MM%22">Bahaa MM</searchLink>; Pharmacy Practice Department, Faculty of Pharmacy, Horus University, New Damietta, Egypt. mbahaa@horus.edu.eg.; Pharmacy Practice Department, Faculty of Pharmacy, Mansoura National University, Gamasa, Egypt. mbahaa@horus.edu.eg.; Pharmacy Practice Department, Faculty of Pharmacy, East Port said National University, Port Said, Egypt. mbahaa@horus.edu.eg.<br /><searchLink fieldCode="AU" term="%22Hamza+E%22">Hamza E</searchLink>; Department of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Kamel+MM%22">Kamel MM</searchLink>; Psychiatry Department, Faculty of Medicine, Tanta University, Tanta, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Hanafy+DA%22">El-Hanafy DA</searchLink>; Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.<br /><searchLink fieldCode="AU" term="%22Eltantawy+N%22">Eltantawy N</searchLink>; Clinical Pharmacy Department, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Yasser+M%22">Yasser M</searchLink>; Pharmaceutical Technology Department, Faculty of Pharmacy, Port Said University, Port Said, Egypt.; Pharmaceutical Technology Department, Faculty of Pharmacy, East Port Said National University, Port Said, Egypt.<br /><searchLink fieldCode="AU" term="%22Al-Dhelaan+RA%22">Al-Dhelaan RA</searchLink>; Department of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Radwan+KH%22">Radwan KH</searchLink>; Biochemistry Department, Faculty of Physical Therapy, Horus University- Egypt, New Damietta, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Sayed+AA%22">El-Sayed AA</searchLink>; Clinical Pharmacy Department, Faculty of Pharmacy, Sinai University, Alarish Campus, Sinai, Egypt.<br /><searchLink fieldCode="AU" term="%22Eladaroussy+MM%22">Eladaroussy MM</searchLink>; Histology and Cell Biology Department, Faculty of Medicine, Horus University-Egypt, New Damietta, Egypt.<br /><searchLink fieldCode="AU" term="%22Kamaleldein+Rizk+KA%22">Kamaleldein Rizk KA</searchLink>; Histology and Cell Biology Department, Faculty of Medicine, Horus University-Egypt, New Damietta, Egypt.<br /><searchLink fieldCode="AU" term="%22Ebrahim+MHE%22">Ebrahim MHE</searchLink>; Histology and Cell Biology Department, Faculty of Medicine, Horus University-Egypt, New Damietta, Egypt.<br /><searchLink fieldCode="AU" term="%22Elshorbagi+N%22">Elshorbagi N</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Sinai University, East Kantara Branch, New City, Ismailia, , Egypt.
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