Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion.

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Title: Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion.
Authors: Melhem A; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany.; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany., Pregler BEF; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany.; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany., Rodriguez-Gatica JE; Functional Neuroconnectomics Group, Institute for Experimental Epileptology and Cognition Research, University of Bonn, University Hospital Bonn, Bonn, Germany., Friker LL; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany.; Institute of Experimental Oncology, University of Bonn, University Hospital Bonn, Bonn, Germany.; Institute of Neuropathology, University of Bonn, University Hospital Bonn, Bonn, Germany., Thomas J; Biology of Inflammation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany., Toma MI; Department of Pathology, University Hospital Bonn, Bonn, Germany., Westhoff MA; German Center for Child and Adolescent Health (DZKJ), partner site Ulm, Ulm, Germany., Ravi VM; Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.; Faculty of Medicine, Freiburg University, Freiburg, Germany.; 3D Brain Models Lab for Neurodegenerative Diseases, Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany., Borger V; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany., Heiland DH; Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.; Faculty of Medicine, Freiburg University, Freiburg, Germany.; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, University Hospital Erlangen, Erlangen, Germany., Layer JP; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany.; Institute of Experimental Oncology, University of Bonn, University Hospital Bonn, Bonn, Germany.; Department of Radiotherapy and Radiation Oncology, University of Bonn, University Hospital Bonn, Bonn, Germany., Schlitzer A; Biology of Inflammation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany., Pietsch T; Institute of Neuropathology, University of Bonn, University Hospital Bonn, Bonn, Germany., Hölzel M; Institute of Experimental Oncology, University of Bonn, University Hospital Bonn, Bonn, Germany., Waha A; Institute of Neuropathology, University of Bonn, University Hospital Bonn, Bonn, Germany., Vatter H; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany., Schwarz MK; Functional Neuroconnectomics Group, Institute for Experimental Epileptology and Cognition Research, University of Bonn, University Hospital Bonn, Bonn, Germany., Herrlinger U; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany.; Department of Neurooncology, Center for Neurology, University of Bonn, University Hospital Bonn, Bonn, Germany., Kubitscheck U; Clausius Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany., Potthoff AL; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany.; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany., Schneider M; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany. matthias.schneider@ukbonn.de.; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany. matthias.schneider@ukbonn.de.
Source: Nature protocols [Nat Protoc] 2026 Jul 28. Date of Electronic Publication: 2026 Jul 28.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1750-2799
DOI:10.1038/s41596-026-01412-3