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Robust CD4+ CAR T cell expansion is associated with non-ICANS neurotoxicities after ciltacabtagene autoleucel in patients with multiple myeloma.

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Title: Robust CD4+ CAR T cell expansion is associated with non-ICANS neurotoxicities after ciltacabtagene autoleucel in patients with multiple myeloma.
Authors: Jurgens EM; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Mitra S; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Herrera K; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Nemirovsky D; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Bready B; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Derkach A; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Hosszu K; Immune Discovery and Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., McAvoy D; Immune Discovery and Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Firestone RS; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Rajeeve S; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Lesokhin AM; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Korde N; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Tan CR; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Hashmi H; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Hassoun H; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Maclachlan K; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Shah UA; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Hultcrantz M; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Merz M; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Maura F; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Giralt SA; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Shah GL; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Landau HJ; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Scordo M; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Kotchetkov IS; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Santomasso BD; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Park J; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Leslie CS; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Usmani SZ; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Perica K; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Mailankody S; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Jul 29; Vol. 18 (860), pp. eaed0039. Date of Electronic Publication: 2026 Jul 29.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.aed0039