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Robust CD4+ CAR T cell expansion is associated with non-ICANS neurotoxicities after ciltacabtagene autoleucel in patients with multiple myeloma.

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Title: Robust CD4+ CAR T cell expansion is associated with non-ICANS neurotoxicities after ciltacabtagene autoleucel in patients with multiple myeloma.
Authors: Jurgens EM; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Mitra S; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Herrera K; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Nemirovsky D; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Bready B; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Derkach A; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Hosszu K; Immune Discovery and Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., McAvoy D; Immune Discovery and Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Firestone RS; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Rajeeve S; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Lesokhin AM; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Korde N; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Tan CR; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Hashmi H; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Hassoun H; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Maclachlan K; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Shah UA; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Hultcrantz M; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Merz M; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Maura F; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Giralt SA; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Shah GL; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Landau HJ; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Scordo M; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Kotchetkov IS; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Santomasso BD; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Park J; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Leslie CS; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Usmani SZ; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA., Perica K; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Mailankody S; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Jul 29; Vol. 18 (860), pp. eaed0039. Date of Electronic Publication: 2026 Jul 29.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Robust CD4<superscript>+</superscript> CAR T cell expansion is associated with non-ICANS neurotoxicities after ciltacabtagene autoleucel in patients with multiple myeloma.
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  Data: <searchLink fieldCode="AU" term="%22Jurgens+EM%22">Jurgens EM</searchLink>; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Mitra+S%22">Mitra S</searchLink>; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Herrera+K%22">Herrera K</searchLink>; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Nemirovsky+D%22">Nemirovsky D</searchLink>; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Bready+B%22">Bready B</searchLink>; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Derkach+A%22">Derkach A</searchLink>; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Hosszu+K%22">Hosszu K</searchLink>; Immune Discovery and Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22McAvoy+D%22">McAvoy D</searchLink>; Immune Discovery and Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Firestone+RS%22">Firestone RS</searchLink>; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Rajeeve+S%22">Rajeeve S</searchLink>; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Lesokhin+AM%22">Lesokhin AM</searchLink>; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Korde+N%22">Korde N</searchLink>; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Tan+CR%22">Tan CR</searchLink>; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Hashmi+H%22">Hashmi H</searchLink>; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Hassoun+H%22">Hassoun H</searchLink>; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Maclachlan+K%22">Maclachlan K</searchLink>; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Shah+UA%22">Shah UA</searchLink>; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Hultcrantz+M%22">Hultcrantz M</searchLink>; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Merz+M%22">Merz M</searchLink>; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Maura+F%22">Maura F</searchLink>; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Giralt+SA%22">Giralt SA</searchLink>; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Shah+GL%22">Shah GL</searchLink>; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Landau+HJ%22">Landau HJ</searchLink>; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Scordo+M%22">Scordo M</searchLink>; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Kotchetkov+IS%22">Kotchetkov IS</searchLink>; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Santomasso+BD%22">Santomasso BD</searchLink>; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Leslie+CS%22">Leslie CS</searchLink>; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Usmani+SZ%22">Usmani SZ</searchLink>; Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Perica+K%22">Perica K</searchLink>; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Mailankody+S%22">Mailankody S</searchLink>; Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
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