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Sophoridine attenuates osteoarthritis progression: association with suppression of chondrocyte pyroptosis via inhibiting NF-κB signaling pathway.

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Title: Sophoridine attenuates osteoarthritis progression: association with suppression of chondrocyte pyroptosis via inhibiting NF-κB signaling pathway.
Authors: Zhang L; Department of Physiology, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., Xing X; Department of Physiology, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., Zhou C; Institute of Orthopaedic and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China., Fu F; Institute of Orthopaedic and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China., Chen Z; Institute of Orthopaedic and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China., Wu C; Institute of Orthopaedic and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China., Ruan H; Institute of Orthopaedic and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China., Yue M; Department of Physiology, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.; Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Jul 15; Vol. 17, pp. 1861567. Date of Electronic Publication: 2026 Jul 15 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Sophoridine attenuates osteoarthritis progression: association with suppression of chondrocyte pyroptosis via inhibiting NF-κB signaling pathway.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Physiology, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Xing+X%22">Xing X</searchLink>; Department of Physiology, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhou+C%22">Zhou C</searchLink>; Institute of Orthopaedic and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Fu+F%22">Fu F</searchLink>; Institute of Orthopaedic and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Institute of Orthopaedic and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Institute of Orthopaedic and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Ruan+H%22">Ruan H</searchLink>; Institute of Orthopaedic and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Yue+M%22">Yue M</searchLink>; Department of Physiology, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.; Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media]%22">Frontiers Media] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101548923 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-9812 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216639812%22">16639812 </searchLink><i>NLM ISO Abbreviation: </i>Front Pharmacol <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.3389/fphar.2026.1861567
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              Text: 2026 Jul 15
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