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A critical review of the early clozapine trials published in German and a discussion of the many unresolved issues left by these trials.

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Title: A critical review of the early clozapine trials published in German and a discussion of the many unresolved issues left by these trials.
Authors: Ferrea S; Adult Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland., de Leon J; Mental Health Research Center, Eastern State Hospital, Lexington, KY, USA.; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain., Baumann P; Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly-Lausanne, Switzerland., Benkert O; Department of Psychiatry, University of Mainz, Mainz, Germany., Helmchen H; Charité - Universitätsmedizin Berlin, Berlin, Germany., Correll CU; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, NY, USA.; Department of Psychiatry, Zucker School of Medicine at Northwell/Hofstra, Hempstead, NY, USA.; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany., Schoretsanitis G; Adult Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland. george.schor@gmail.com.; Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly-Lausanne, Switzerland. george.schor@gmail.com.; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, NY, USA. george.schor@gmail.com.; Department of Psychiatry, Zucker School of Medicine at Northwell/Hofstra, Hempstead, NY, USA. george.schor@gmail.com.; Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. george.schor@gmail.com.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Aug 01. Date of Electronic Publication: 2026 Aug 01.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A critical review of the early clozapine trials published in German and a discussion of the many unresolved issues left by these trials.
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  Data: <searchLink fieldCode="AU" term="%22Ferrea+S%22">Ferrea S</searchLink>; Adult Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22de+Leon+J%22">de Leon J</searchLink>; Mental Health Research Center, Eastern State Hospital, Lexington, KY, USA.; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain.<br /><searchLink fieldCode="AU" term="%22Baumann+P%22">Baumann P</searchLink>; Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly-Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Benkert+O%22">Benkert O</searchLink>; Department of Psychiatry, University of Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Helmchen+H%22">Helmchen H</searchLink>; Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Correll+CU%22">Correll CU</searchLink>; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, NY, USA.; Department of Psychiatry, Zucker School of Medicine at Northwell/Hofstra, Hempstead, NY, USA.; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schoretsanitis+G%22">Schoretsanitis G</searchLink>; Adult Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland. george.schor@gmail.com.; Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Prilly-Lausanne, Switzerland. george.schor@gmail.com.; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, NY, USA. george.schor@gmail.com.; Department of Psychiatry, Zucker School of Medicine at Northwell/Hofstra, Hempstead, NY, USA. george.schor@gmail.com.; Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. george.schor@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%220326264%22">Naunyn-Schmiedeberg's archives of pharmacology</searchLink> [Naunyn Schmiedebergs Arch Pharmacol] 2026 Aug 01. <i>Date of Electronic Publication: </i>2026 Aug 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0326264 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1912 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200281298%22">00281298 </searchLink><i>NLM ISO Abbreviation: </i>Naunyn Schmiedebergs Arch Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00210-026-05742-7
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        Text: English
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              Text: 2026 Aug 01
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