V600E biases the BRAF kinase domain toward an activation-compatible conformational ensemble through long-range dynamic rewiring.

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Title: V600E biases the BRAF kinase domain toward an activation-compatible conformational ensemble through long-range dynamic rewiring.
Authors: Zhang BD; College of Agriculture and Biological Science, Dali University Dali 671000 China ylqbioinfo@dali.edu.cn pengsang@dali.edu.cn.; Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University Dali 671000 China.; Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Development of Yunnan Province, Dali University Dali 671000 China., Xi Q; College of Agriculture and Biological Science, Dali University Dali 671000 China ylqbioinfo@dali.edu.cn pengsang@dali.edu.cn.; Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University Dali 671000 China.; Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Development of Yunnan Province, Dali University Dali 671000 China., Ying YM; College of Agriculture and Biological Science, Dali University Dali 671000 China ylqbioinfo@dali.edu.cn pengsang@dali.edu.cn.; Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University Dali 671000 China.; Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Development of Yunnan Province, Dali University Dali 671000 China., Zhao DR; College of Agriculture and Biological Science, Dali University Dali 671000 China ylqbioinfo@dali.edu.cn pengsang@dali.edu.cn.; Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University Dali 671000 China.; Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Development of Yunnan Province, Dali University Dali 671000 China., Yang LQ; College of Agriculture and Biological Science, Dali University Dali 671000 China ylqbioinfo@dali.edu.cn pengsang@dali.edu.cn.; Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University Dali 671000 China.; Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Development of Yunnan Province, Dali University Dali 671000 China., Sang P; College of Agriculture and Biological Science, Dali University Dali 671000 China ylqbioinfo@dali.edu.cn pengsang@dali.edu.cn.; Key Laboratory of Bioinformatics and Computational Biology of the Department of Education of Yunnan Province, Dali University Dali 671000 China.; Co-Innovation Center for Cangshan Mountain and Erhai Lake Integrated Protection and Green Development of Yunnan Province, Dali University Dali 671000 China.
Source: RSC advances [RSC Adv] 2026 Aug 11; Vol. 16 (40), pp. 46674-46689. Date of Electronic Publication: 2026 Aug 11 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2046-2069
DOI:10.1039/d6ra04733e