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Optogenetic tachypacing facilitates burst-induced arrhythmia in stem cell-derived human atrial engineered heart tissue.

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Title: Optogenetic tachypacing facilitates burst-induced arrhythmia in stem cell-derived human atrial engineered heart tissue.
Authors: Müller KF; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Department of Cardiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Pan B; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Institute of Experimental Cardiology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Ridder J; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Department of Cardiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; University Center of Cardiovascular Science, University Heart and Vascular Center Hamburg, 20246 Hamburg, Germany., Schrapers J; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany., Hansen J; Sarcura GmbH, 3400 Klosterneuburg, Austria., Meier TM; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany., Schulz C; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Department of Cardiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Stüdemann T; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany., Lemme M; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; Nanion Technologies GmbH, 80339 Munich, Germany., Krause J; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Department of Cardiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Hirt MN; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; University Center of Cardiovascular Science, University Heart and Vascular Center Hamburg, 20246 Hamburg, Germany., Stoter AMS; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany., Braren I; Vector Facility, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Spohn M; Bioinformatics Core Facility, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Weinberger F; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Research Group Tissue Engineering and Regenerative Therapies, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Fabritz L; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.; Department of Cardiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; University Center of Cardiovascular Science, University Heart and Vascular Center Hamburg, 20246 Hamburg, Germany., Duan X; Department of Neurophysiology, Institute of Physiology, University of Würzburg, Würzburg, Germany.; Department of Neuroscience, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China., Gao S; Department of Neurophysiology, Institute of Physiology, University of Würzburg, Würzburg, Germany., Gee CE; Department of Synaptic Neuroscience, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Hansen A; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany., Eschenhagen T; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany., Christ T; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany., Stenzig J; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Source: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology [Europace] 2026 Aug 04; Vol. 28 (8).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100883649 Publication Model: Print Cited Medium: Internet ISSN: 1532-2092 (Electronic) Linking ISSN: 10995129 NLM ISO Abbreviation: Europace Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1532-2092
DOI:10.1093/europace/euag158