IRE1 activity is prognostic in localised and metastatic prostate cancer and affects epithelial lineage states.
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| Title: | IRE1 activity is prognostic in localised and metastatic prostate cancer and affects epithelial lineage states. |
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| Authors: | Doultsinos D; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. dimitrios.doultsinos@nds.ox.ac.uk., Tomljanovic I; Department of Urology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, the Netherlands., Pilalis E; e-NIOS PC, Kallithea-Athens, Greece., Abusamra SM; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Alshalalfa M; Veracyte, South San Francisco, CA, USA., Parmentier R; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.; Department of Urology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, University Hospital Basel, Basel, Switzerland., Ahire V; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Bridges IE; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Figiel S; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Hester J; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Leach D; Imperial College London, London, UK., Nandakumar A; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Wan R; Department of Urology, UCSF, San Francisco, CA, USA., Zekri Y; Division of Oncogenomics, The Netherlands Cancer Insitute, 1066 CX, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands., Zhang J; Faculty of Biomedical Sciences, Institute of Oncology Research, USI, Bellinzona, TI, 6500, Switzerland., Bevan CL; Imperial College London, London, UK., O'Neill E; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Lamb AD; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK., Macauley V; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Theurillat JP; Faculty of Biomedical Sciences, Institute of Oncology Research, USI, Bellinzona, TI, 6500, Switzerland., Urbanucci A; Center for Cancer Eradication Research, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere, Finland.; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., Karnes RJ; Mayo Clinic Dept of Urology, Rochester, MN, USA., Spratt DE; University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH, USA., Davicioni E; Veracyte, South San Francisco, CA, USA., Quigley D; Department of Urology, UCSF, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, USA., Zwart W; Division of Oncogenomics, The Netherlands Cancer Insitute, 1066 CX, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands., Le Magnen C; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.; Department of Urology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, University Hospital Basel, Basel, Switzerland., Chatziioannou A; e-NIOS PC, Kallithea-Athens, Greece.; Center of Systems Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Mills IG; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. ian.mills@nds.ox.ac.uk. |
| Source: | EMBO molecular medicine [EMBO Mol Med] 2026 Oct; Vol. 18 (10), pp. 3898-3938. Date of Electronic Publication: 2026 Aug 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1757-4684 |
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| DOI: | 10.1038/s44321-026-00490-w |
