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Association between canakinumab dose and long-term remission in Still's disease: insights from the AIDA network registry.

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Title: Association between canakinumab dose and long-term remission in Still's disease: insights from the AIDA network registry.
Authors: Vitale A; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] Siena, Siena, Italy., Caggiano V; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] Siena, Siena, Italy., Sbalchiero J; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] Siena, Siena, Italy., Lopalco G; Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, Italy., Tufan A; Gazi University Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Türkiye., Ragab G; Internal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Giza, Egypt., Sfikakis PP; Joint Academic Rheumatology Program, Medical School, National and Kapodistrian University of Athens, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Athens, Greece., Dagna L; Faculty of Medicine, Università Vita-Salute San Raffaele, Milan, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Milan, Italy., Batu ED; Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University School of Medicine, Ankara, Türkiye., Ozen S; Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University School of Medicine, Ankara, Türkiye., Conti F; Department of Internal Medicine and Medical Specialties, Rheumatology Unit, AOU Policlinico Umberto I, Sapienza University of Rome, Rome, Italy., Maiolini F; Azienda Ospedaliera Universitaria Integrata of Verona, Internal Medicine, Immunology Unit, Verona, Italy., Bugatti S; Department of Internal Medicine and Therapeutics, Università di Pavia, Italy; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Pavia, Italy., Frassi M; Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Brescia, Italy., Ruscitti P; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Morrone M; Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, Italy., La Torre F; Department of Pediatrics, Pediatric Rheumatology Center (F.L.T.), Giovanni XXIII Pediatric Hospital, University of Bari Aldo Moro, Bari, Italy., Cakir IY; Gazi University Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Türkiye., Akay N; Department of Paediatrics, Division of Paediatric Rheumatology, Istanbul University-Cerrahpasa, Faculty of Medicine, Istanbul, Türkiye., Kilic Konte E; Department of Paediatrics, Division of Paediatric Rheumatology, Istanbul University-Cerrahpasa, Faculty of Medicine, Istanbul, Türkiye., Laskari K; Joint Academic Rheumatology Program, Medical School, National and Kapodistrian University of Athens, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Athens, Greece., Bilginer Y; Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University School of Medicine, Ankara, Türkiye., Gattamelata A; Department of Internal Medicine and Medical Specialties, Rheumatology Unit, AOU Policlinico Umberto I, Sapienza University of Rome, Rome, Italy., Croce J; Azienda Ospedaliera Universitaria Integrata of Verona, Internal Medicine, Immunology Unit, Verona, Italy., De Stefano L; Department of Internal Medicine and Therapeutics, Università di Pavia, Italy; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Pavia, Italy., Voltarel G; Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Brescia, Italy., Cipriani P; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Maggio MC; University Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) 'G. D'Alessandro', University of Palermo, Palermo, Italy., Al-Mayouf SM; Department of Pediatrics, King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Fotis L; Department of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece., Rigante D; Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.; Periodic Fever Research Center, Università Cattolica Sacro Cuore, Rome, Italy., Sota J; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] Siena, Siena, Italy., Verrecchia E; Periodic Fever Research Center, Università Cattolica Sacro Cuore, Rome, Italy.; Department of Aging, Neurological, Orthopedic and Head and Neck Sciences, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy., Guggino G; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology Unit, P. Giaccone University Hospital, University of Palermo, Palermo, Italy., La Barbera L; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology Unit, P. Giaccone University Hospital, University of Palermo, Palermo, Italy., Piga M; Rheumatology Unit, Department of Medical Sciences and Public Health, University and AOU of Cagliari, Cagliari, Italy., Emmi G; Department of Medical, Surgical and Health Sciences, University of Trieste, Italy, and Clinical Medicine and Rheumatology Unit, Cattinara University Hospital, Trieste, Italy.; Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, Clayton, VIC, Australia., Gallizzi R; Pediatric Rheumatology Department of Health Sciences, Magna Graecia University, Catanzaro, Italy., Conti G; Pediatric Nephrology and Rheumatology Unit, Azienda Ospedaliero Universitaria (AOU) G Martino, Messina, Italy., Sfriso P; Rheumatology Unit, Department of Medicine, University of Padua, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Padua, Italy., Bartoloni E; Rheumatology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Giacomelli R; Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Rome, Italy.; Rheumatology and Clinical Immunology, Department of Medicine, University of Rome Campus Bio-Medico, School of Medicine, Rome, Italy., Barone P; Pediatric Rheumatology Unit, Department of Integrated Maternal-Child and Reproduction Activity, AOU 'Policlinico-San Marco', Catania, Italy., Olivieri AN; Department of Woman, Child and of General and Specialized Surgery, University of Campania ``Luigi Vanvitelli'', Naples, Italy., Alemanno A; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] Siena, Siena, Italy., Lo Gullo A; Unit of Rheumatology, Department of Medicine, ARNAS Garibaldi Hospital, Catania, Italy., Direskeneli H; Division of Rheumatology, Department of Internal Medicine, School of Medicine, Marmara University, Istanbul, Türkiye., Alibaz-Oner F; Division of Rheumatology, Department of Internal Medicine, School of Medicine, Marmara University, Istanbul, Türkiye., Karamanakos A; Department of Rheumatology, 'Evangelismos' General Hospital, Athens, Greece., Prete M; Rheumatic and Systemic Autoimmune Diseases Unit, Department of Interdisciplinary Medicine (DIM), University of Bari Medical School, Bari, Italy., Edrees A; Division of Rheumatology, University of Missouri, Kansas City, MO, United States., Gavioli F; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] Siena, Siena, Italy., Parronchi P; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Ciccia F; Department of Precision Medicine, Rheumatology Section, University of Campania Luigi Vanvitelli, Naples, Italy., Cardamone C; UOC of Internal Medicine, Rheumatology Outpatients Unit, Azienda Ospedaliero-Universitaria San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy., Hernández-Rodríguez J; Department of Autoimmune Diseases, Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic of Barcelona [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Barcelona, Barcelona, Spain., Hatemi G; Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Türkiye.; Behçet's Disease Research Center, Istanbul University-Cerrahpasa, Istanbul, Türkiye., Bes C; Department of Rheumatology, University of Health Sciences Başakşehir Çam and Sakura City Hospital, Istanbul, Türkiye., Almaghlouth IA; Rheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.; College of Medicine Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Marhuenda ÁR; Department of Internal Medicine, Autoimmune Disease Unit, Hospital Universitario La Paz, Madrid, Spain., Gonzáles-García A; Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain., Gaggiano C; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] Siena, Siena, Italy., De Paulis A; Department of Translational Medical Sciences, Section of Clinical Immunology, University of Naples Federico II, Naples, Italy., Tezcan ME; Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence, University of Naples Federico II, Naples, Italy., Brucato AL; Department of Biomedical and Clinical Sciences, Fatebenefratelli Hospital, Università di Milano, Milan, Italy., Feist E; Department of Rheumatology and Clinical Immunology, Helios Fachklinik Vogelsang-Gommern Klinik für Rheumatologie, Gommern, Germany.; Experimental Rheumatology, Otto-von-Guericke Universität Magdeburg, Magdeburg, Germany., Tornero-Romero F; Autoimmune Diseases Unit, Department of Internal Medicine, Fundación Jiménez Díaz University Hospital, Madrid, Spain., Suzon B; Department of Internal Medicine, Martinique University Hospital, Fort-de-France, Martinique., Ogunjimi B; Antwerp Center for Translational Immunology and Virology (ACTIV), Center for Health Economics Research and Modeling Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.; Division of Paediatric Rheumatology, Department of Paediatrics, Antwerp University Hospital (UZA), Antwerp, Belgium.; Division of Paediatric Rheumatology, Department of Paediatrics, Kidz Health Castle Universitair Ziekenhuis Brussel (UZB), Jette, Belgium.; Division of Paediatric Rheumatology, Department of Rheumatology, Ziekenhuis Aan de Stroom (ZAS), Antwerp, Belgium., Thabet M; Internal Medicine Department, Farhat Hached University Hospital, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia., Conforti A; Ospedale San Paolo Di Civitavecchia, U.O. Medicina Generale, ASL Roma 4, Civitavecchia, Italy., Pucino V; Clinical Immunology and Allergy Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Boyarchuk O; Department of Children's Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine., Kovalchuk T; Department of Children's Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine., Govoni M; Rheumatology Unit, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, University of Ferrara, Ferrara, Italy., Iagnocco A; Academic Rheumatology Center, Dipartimento Scienze Cliniche e Biologiche, Università Degli Studi Di Torino, Turin, Italy., Chimenti MS; Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Moshrif A; Rheumatology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt., Del Giudice E; Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Polo Pontino, Rome, Italy., Carubbi F; Department of Life, Health and Environmental Sciences, University of L'Aquila; Internal Medicine and Nephrology Division, Avezzano-Sulmona-L'Aquila Local Health Authority 1, San Salvatore Hospital, L'Aquila, Italy., Erten Ş; Department of Rheumatology, Ankara Bilkent City Hospital, Ankara Yıldırım Beyazıt University, Ankara, Türkiye., Tharwat S; Rheumatology and Immunology Unit (S.T.), Internal Medicine Department, Mansoura University, Mansoura, Egypt.; Department of Internal Medicine, Faculty of Medicine, Horus University, New Damietta, Egypt., Hegazy MT; Internal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Giza, Egypt.; Internal Medicine Department, Rheumatology Unit, Jahra Hospital, Al Jahra, Kuwait., Więsik-Szewczyk E; Department of Internal Medicine, Pneumonology, Allergology, Clinical Immunology and Rare Diseases, Military Institute of Medicine, National Research Institute, Warsaw, Poland., Torres-Ruiz J; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Martín-Nares E; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Balistreri A; Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] Siena, Siena, Italy.; Bioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena, Siena, Italy., Fabiani C; Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] Siena, Siena, Italy.; Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy., Frediani B; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] Siena, Siena, Italy., Hinojosa-Azaola A; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Kasapçopur Ö; Department of Paediatrics, Division of Paediatric Rheumatology, Istanbul University-Cerrahpasa, Faculty of Medicine, Istanbul, Türkiye., Cantarini L; Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.; Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] Siena, Siena, Italy.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Aug 10; Vol. 17, pp. 1846937. Date of Electronic Publication: 2026 Aug 10 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:1663-9812
DOI:10.3389/fphar.2026.1846937